Abstract

The Pilot Project Program has always played a major role in defining the identity ofthe MIT CEHS and in refreshing the Center membership. In addition to open calls for proposals to the MIT community, the Program complements the Director's Opportunity Fund by providing a means to target the development of new research areas in environmental health sciences and toxicology and to foster new activities such as the Global EHS Program, with focused calls for proposals. The funds used to support the Pilot Project Program, which amounted to $638K in the past funding period, represent a sound investment in EHS research at MIT, with a 17-fold return in terms of leveraging new grant funding. The Pilot Project Program will continue to be of central importance to the CEHS in the next funding period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES002109-33
Application #
8466326
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
33
Fiscal Year
2013
Total Cost
$204,697
Indirect Cost
$80,681

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Rizzo, Alessandro A; Vassel, Faye-Marie; Chatterjee, Nimrat et al. (2018) Rev7 dimerization is important for assembly and function of the Rev1/Pol? translesion synthesis complex. Proc Natl Acad Sci U S A 115:E8191-E8200
Kulik, Heather J (2018) Large-scale QM/MM free energy simulations of enzyme catalysis reveal the influence of charge transfer. Phys Chem Chem Phys 20:20650-20660
Gu, Chen; Ramos, Jillian; Begley, Ulrike et al. (2018) Phosphorylation of human TRM9L integrates multiple stress-signaling pathways for tumor growth suppression. Sci Adv 4:eaas9184
Zamora, Cristina Y; Madec, Amaël G E; Neumann, Wilma et al. (2018) Design, solid-phase synthesis and evaluation of enterobactin analogs for iron delivery into the human pathogen Campylobacter jejuni. Bioorg Med Chem 26:5314-5321
Wong, Madeline Y; Chen, Kenny; Antonopoulos, Aristotelis et al. (2018) XBP1s activation can globally remodel N-glycan structure distribution patterns. Proc Natl Acad Sci U S A 115:E10089-E10098
Hadley, Rose C; Gagnon, Derek M; Brophy, Megan Brunjes et al. (2018) Biochemical and Spectroscopic Observation of Mn(II) Sequestration from Bacterial Mn(II) Transport Machinery by Calprotectin. J Am Chem Soc 140:110-113
Lieberman, Mia T; Van Tyne, Daria; Dzink-Fox, JoAnn et al. (2018) Long-Term Colonization Dynamics of Enterococcus faecalis in Implanted Devices in Research Macaques. Appl Environ Microbiol 84:
Wadduwage, Dushan N; Kay, Jennifer; Singh, Vijay Raj et al. (2018) Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice. Sci Rep 8:12108
Jackson, Megan N; Oh, Seokjoon; Kaminsky, Corey J et al. (2018) Strong Electronic Coupling of Molecular Sites to Graphitic Electrodes via Pyrazine Conjugation. J Am Chem Soc 140:1004-1010
Chen, Percival Yang-Ting; Funk, Michael A; Brignole, Edward J et al. (2018) Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase. J Biol Chem 293:10404-10412

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