The Marine and Freshwater Biomedical Sciences Center (MFBSC) uses aquatic species as models of human disease. The MFBSC consists of 6 Cores - 2 Research, 2 Facilities and Services, a Community Outreach, and a Pilot Project and Program Enrichment Core. The 2 Research Cores are supported by extramural grants and OSU, and no research funds or salary are requested. The Director utilizes Internal and Extemal Advisory Committees for guidance on scientific and administrative issues. The MFBSC provides facilities and training for scientists using aquatic models in biomedical research. Training (two NIEHS Training Grants) at the graduate, undergraduate, and postdoctoral levels are important goals of the MFBSC as is education and outreach (also supported by an NIEHS grant) to multiple community groups, including K-12 educators and the general public. The Center maintains its strengths in carcinogenesis, cancer chemoprevention, neurotoxicology and marine natural products. Addition of new faculty expands the focus into developmental toxicology and toxicogenomics. Successful synergism is evidenced by joint grants and publications. A new effort in toxicogenomics provides evidence of synergism among MFBS Centers. The MFBSC makes possible the pursuit of studies of environmental health important regionally, nationally and internationally. Important contributions in the last funding period include: 1) A successful clinical trial in China (directed by the NIEHS Center at Johns Hopkins with G. Bailey as Co-I) of a cancer chemopreventive agent first identified in the trout tumor model; 2) Completion of the largest cancer study in any animal model, that lowered the limit of detection of tumor incidence by more than an order of magnitude and tested the conservative linear model for risk extrapolation; 3) Development of a mobi(e fish cell biosensor of neurotoxins, including nerve gas agents; and 4) Discovery of several extremely potent neurotoxins from marine cyanobacteria that give new insights into the structure and function of the mammalian voltage-gated sodium channel, and may have therapeutic uses. Our goal over the next 5-year funding period is to build on these accomplishments by employing new approaches and technologies to pursue studies on the impacts of environmental chemicals on human health and conveying that information effectively to the public.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES003850-22
Application #
7036581
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
22
Fiscal Year
2006
Total Cost
$422,645
Indirect Cost
Name
Oregon State University
Department
Type
Organized Research Units
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
Harper, Bryan J; Clendaniel, Alicea; Sinche, Federico et al. (2016) Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish. Cellulose (Lond) 23:1763-1775
Cooper, T K; Murray, K N; Spagnoli, S et al. (2015) Primary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio). Vet Pathol 52:388-92
Pettersson, B M Fredrik; Das, Sarbashis; Behra, Phani Rama Krishna et al. (2015) Comparative Sigma Factor-mRNA Levels in Mycobacterium marinum under Stress Conditions and during Host Infection. PLoS One 10:e0139823
Qin, Min; Landriscina, Angelo; Rosen, Jamie M et al. (2015) Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response. J Invest Dermatol 135:2723-2731
Mordorski, Breanne; Pelgrift, Robert; Adler, Brandon et al. (2015) S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology. Nanomedicine 11:283-91
Pryor, Joseph B; Harper, Bryan J; Harper, Stacey L (2014) Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish. Int J Nanomedicine 9:1947-56
Harper, Bryan; Sinche, Federico; Wu, Rosina Ho et al. (2014) The Impact of Surface Ligands and Synthesis Method on the Toxicity of Glutathione-Coated Gold Nanoparticles. Nanomaterials (Basel) 4:355-371
Park, Kwangsik; Tuttle, George; Sinche, Federico et al. (2013) Stability of citrate-capped silver nanoparticles in exposure media and their effects on the development of embryonic zebrafish (Danio rerio). Arch Pharm Res 36:125-33
Thomas, Dennis G; Gaheen, Sharon; Harper, Stacey L et al. (2013) ISA-TAB-Nano: a specification for sharing nanomaterial research data in spreadsheet-based format. BMC Biotechnol 13:2
Liu, Xiong; Tang, Kaizhi; Harper, Stacey et al. (2013) Predictive modeling of nanomaterial exposure effects in biological systems. Int J Nanomedicine 8 Suppl 1:31-43

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