I. Overview The mission of the Career Development Core (CDC) is to provide career training for the new generation of environmental health (EH) scientists, to nurture young faculty and foster their transition to independence, and to attract established scientists and integrate their disciplines into the area of EH. The philosophy of the CDC is that career training is a continuum starting with doctoral training (Ph.D./M.D.) and proceeding through postdoctoral training and subsequent development as junior faculty. Thus graduate and postdoctoral training are equally important for the trajectory of EH science (EHS) professionals. Special emphasis is placed on the career training of clinician-scientists who might not otherwise identify their interests in EH. Women and underrepresented minorities are highly sought as participants. Senior investigators will also be attracted to the field by the appeal of the multidisciplinary paradigm championed by the CDC. The CDC fosters translational and clinical careers in EH sciences by involving an interactive group of scientists from multiple UA Colleges, Departments, and Centers of Excellence, all interested in exploring the role of the environment in disease pathogenesis. Exposure of junior investigators to a multidisciplinary culture, close mentoring by basic and clinical scientists, and access to state-of the-art, empowering technologies will ensure the emergence of a new generation of skilled investigators and provide them with an edge that will foster their career progression to seniority. An outstanding track record of productive collaborations renders the CDC faculty uniquely qualified to spearhead the innovative mentoring endeavor proposed herein. The goals of the CDC are (a) to continue to develop our NIEHS-supported graduate training programs in Toxicology and EHS;(b) to submit Training Grants in EHS to benefit both basic and clinician-scientist trainees;(c) to recruit junior faculty as SWEHSC investigators;(d) to further develop mentoring committees and formalized career development plans for junior investigators;(e) to identify candidates that could apply for pilot project funding from the SWEHSC as well as extramural funding in EHS research;and (f) to attract into EHS established investigators from other fields. Each of these components has metrics of success. The CDC has been successful in accomplishing these goals as outlined below.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006694-17
Application #
8464112
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
17
Fiscal Year
2013
Total Cost
$56,646
Indirect Cost
$25,101
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Dodson, Matthew; Liu, Pengfei; Jiang, Tao et al. (2018) Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol :
Griggs, Chanel A; Malm, Scott W; Jaime-Frias, Rosa et al. (2018) Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors. Toxicol Appl Pharmacol 339:110-120
Toth, Erica L; Li, Hui; Dzierlenga, Anika L et al. (2018) Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. Drug Metab Dispos 46:1478-1486
Malm, S W; Amouzougan, E A; Klimecki, W T (2018) Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line. Toxicol In Vitro 50:383-390
Rojo de la Vega, Montserrat; Zhang, Donna D; Wondrak, Georg T (2018) Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Front Pharmacol 9:287
Harris, Alondra P; Ismail, Kareem A; Nunez, Martha et al. (2018) Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart. Toxicol Lett 285:113-120
Dzierlenga, Anika L; Cherrington, Nathan J (2018) Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. J Biochem Mol Toxicol 32:e22035
Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38
Wales, Jessica A; Chen, Cheng-Yu; Breci, Linda et al. (2018) Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase. J Biol Chem 293:1850-1864
Lee, Sang C; Zhang, Jack; Strom, Josh et al. (2017) G-Quadruplex in the NRF2 mRNA 5' Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress. Mol Cell Biol 37:

Showing the most recent 10 out of 942 publications