The Integrative Environmental Health Sciences Facility Core (lEHSFC) serves the CEEH as a focal point for interdisciplinary research, the portal for accessing Center services, and a comprehensive consultation resource to assist CEEH investigators and trainees, emphasizing clinical, translational, and population-based studies. The lEHSFC allows UW EHS research to move as smoothly as possible not only from "bench-to-bedside" but also from population-based observations to bench to clinical research and onward to public health policy and practice. This facility core builds on a rich history of environmental health translational and epidemiological research at the UW. The lEHSFC facilitates EHS research?including translational research~and fosters the integration of basic sciences research at the University of Washington with population-based and clinical EHS research. The core's mission is to provide access and consultation to CEEH investigators to ensure that the most modern molecular and 'systems biology'approaches are used to identify the interactions between genetic, epigenetic and environmental factors that contribute to the major chronic diseases. The core is comprised of three units: the Clinical/Translational Services Unit (CTSU), the Bioinformatics and Biostatistics Unit (BBU, this unit also includes OMICs integration), and the Technology Access Unit (TAU). The Bioinformatics and Biostatistics Unit provides many of the services that were previously provided by a dedicated Bioinformatics and Biostatistics Core. The other two units provide suites of services that are essentially new in this proposal. While the core offers a myriad of concrete services (and even a dedicated space for clinical evaluation in the CTSU), the core is first and foremost a literal and virtual collaborative space dedicated to encouraging and enabling innovative translational research and collaborations across disciplines at the UW.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Schaupp, Christopher M; White, Collin C; Merrill, Gary F et al. (2015) Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3. Chem Biol Interact 234:154-61
Wegner, Susanna H; Yu, Xiaozhong; Pacheco Shubin, Sara et al. (2015) Stage-specific signaling pathways during murine testis development and spermatogenesis: A pathway-based analysis to quantify developmental dynamics. Reprod Toxicol 51:31-9
Cole, Toby B; Li, Wan-Fen; Co, Aila L et al. (2014) Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci 141:409-22
Hiolski, Emma M; Kendrick, Preston S; Frame, Elizabeth R et al. (2014) Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquat Toxicol 155:151-9
Penning, Trevor M; Breysse, Patrick N; Gray, Kathleen et al. (2014) Environmental health research recommendations from the Inter-Environmental Health Sciences Core Center Working Group on unconventional natural gas drilling operations. Environ Health Perspect 122:1155-9
Woods, James S; Heyer, Nicholas J; Russo, Joan E et al. (2014) Genetic polymorphisms affecting susceptibility to mercury neurotoxicity in children: summary findings from the Casa Pia Children's Amalgam clinical trial. Neurotoxicology 44:288-302
Pizzurro, Daniella M; Dao, Khoi; Costa, Lucio G (2014) Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons. Toxicol Appl Pharmacol 274:372-82
Roth, J A; Boudreau, D; Fujii, M M et al. (2014) Genetic risk factors for major bleeding in patients treated with warfarin in a community setting. Clin Pharmacol Ther 95:636-43
Kemp, Christopher J; Moore, James M; Moser, Russell et al. (2014) CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Rep 7:1020-9
Woods, James S; Heyer, Nicholas J; Russo, Joan E et al. (2014) Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children. J Toxicol Environ Health A 77:293-312

Showing the most recent 10 out of 519 publications