The theme of this Center GEEH is "Biochemical and Molecular Mechanisms Underlying Human Variability in Response to Environmental Exposures". The purpose of this NIEHS Center is to provide an administrative infrastructure and technical support to foster the multidisciplinary collaborations necessary to extend basic mechanistic studies on environmental health problems to direct application in human populations, with an emphasis on "gene x environment" interactions. This Center consists of 45 Core Environmental Health Sciences investigators and 37 other investigators involved in Clinical and Translational Sciences research at the UW, organized in 6 areas of research emphasis (AREs): 1) Genomics of Xenobiotic Disposition, 2) Carcinogenesis and Mutagenesis, 3) Susceptible Subpopulations (Children, Elderly and Women), 4) Neurotoxicology, 5) Cardio-pulmonary Toxicology, 6) Biomarkers and Exposure Assessment. The funded research of these core faculty is enhanced by 3 Facility Cores which provide Center investigators access to: 1) Functional Genomics and Proteomics technologies, including high throughput genotyping, microarray analysis and mass spectrometry based proteomics, 2) Exposure Assessment, Biomarkers and Metabolomics Development, 3) an Integrated Environmental Health Sciences Facility Core that includes Bioinformatics &Biostatistics Services and fosters clinical- and population-based research. Through the Director's Discretionary Fund the CEEH also facilitates Technology Access, by providing subsidized access to numerous Shared Resources and Cost Centers at the UW, including techniques such as analytical cytology, histopathology/morphometry, transgenic animal resources, and small animal and molecular imaging. In addition, each year the Pilot Project Program supports 5 exploratory projects that will carry out innovative and novel research related to the theme of the Center. A Community Outreach and Ethics Core provides a mechanism to disseminate important research findings of Center investigators to the general community, as well as a coordinating function to extend and enhance existing community education programs that emphasize issues related to environmental health sciences. ESSENTIAL CHARACTERISTICS STRATEGIC VISION AND IMPACT ON ENVIRONMENTAL HEALTH

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007033-19
Application #
8650846
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
19
Fiscal Year
2014
Total Cost
$1,714,772
Indirect Cost
$615,559
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Schaupp, Christopher M; White, Collin C; Merrill, Gary F et al. (2015) Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3. Chem Biol Interact 234:154-61
Wegner, Susanna H; Yu, Xiaozhong; Pacheco Shubin, Sara et al. (2015) Stage-specific signaling pathways during murine testis development and spermatogenesis: A pathway-based analysis to quantify developmental dynamics. Reprod Toxicol 51:31-9
Cole, Toby B; Li, Wan-Fen; Co, Aila L et al. (2014) Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci 141:409-22
Hiolski, Emma M; Kendrick, Preston S; Frame, Elizabeth R et al. (2014) Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquat Toxicol 155:151-9
Penning, Trevor M; Breysse, Patrick N; Gray, Kathleen et al. (2014) Environmental health research recommendations from the Inter-Environmental Health Sciences Core Center Working Group on unconventional natural gas drilling operations. Environ Health Perspect 122:1155-9
Woods, James S; Heyer, Nicholas J; Russo, Joan E et al. (2014) Genetic polymorphisms affecting susceptibility to mercury neurotoxicity in children: summary findings from the Casa Pia Children's Amalgam clinical trial. Neurotoxicology 44:288-302
Pizzurro, Daniella M; Dao, Khoi; Costa, Lucio G (2014) Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons. Toxicol Appl Pharmacol 274:372-82
Roth, J A; Boudreau, D; Fujii, M M et al. (2014) Genetic risk factors for major bleeding in patients treated with warfarin in a community setting. Clin Pharmacol Ther 95:636-43
Kemp, Christopher J; Moore, James M; Moser, Russell et al. (2014) CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Rep 7:1020-9
Woods, James S; Heyer, Nicholas J; Russo, Joan E et al. (2014) Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children. J Toxicol Environ Health A 77:293-312

Showing the most recent 10 out of 519 publications