The NIEHS Center for Environmental Health in Northern Manhattan (CEHNM) brings together basic scientists, physicians, epidemiologists, biostatisticians and citizens in a partnership focusing on a central theme that stresses understanding and preventing environmental components of disease. Most of the work of the 33 Center investigators is focused in three main disease areas: cancer, respiratory diseases and neurotoxicology/neurodegenerative diseases. CEHNM members seek to identify and study environmental exposures that contirbute to the pathobiology of human disease, devlelop strategies for prevention and communicate these results to other researchers and the public. Studies range from basic mechanistic studies in cell culture and animals to population studies. The themes of the CEHNM are centered around air toxics/bioaerosols, oxidative stress, gene-environment interactions and epigenetics. While much of our research is focused on a disadvantaged community that receives disproportionally high exposure to hazardous substances in New York City, other projects study health effects of environmental exposures around the world, including Taiwan, Bangladesh, China, Poland and Africa. Research is facilitated by four service cores including: (1) Exposure Assessment, (2) Trace Metals, (3) Integrative Health Sciences and (4) Administrative. In this submission, the formal research cores are eliminated;flexible working groups are now being used to bring together investigators across the disease areas to initiate new areas of collaboration. A successful Pilot Project Program is used to bring in new investigators and ideas. Our Community Outreach and Education Core is an active collaboration between Center investigators and West Harlem Environmental Action (WE ACT). Their activities include community forums, national conferences, mentoring of high school students and various educational activities. A new Career Development Program will further enhance the mentoring of junior faculty currently taking place within the CEHNM. An Executive Committee, composed of the former Research Core leaders, helps the Director administer the program. An External Advisory Committee consisting of outside experts in the research areas covered and an Internal Advisory Committee consisting of eminent scientists with administrative skills provide additional guidance. Strong institutional commitment further strengthens the Center.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
Zip Code
Reynolds, Lindsay M; Magid, Hoda S; Chi, Gloria C et al. (2017) Secondhand Tobacco Smoke Exposure Associations With DNA Methylation of the Aryl Hydrocarbon Receptor Repressor. Nicotine Tob Res 19:442-451
Burris, Heather H; Baccarelli, Andrea A (2017) Air pollution and in utero programming of poor fetal growth. Epigenomics 9:213-216
Colicino, Elena; Wilson, Ander; Frisardi, Maria Chiara et al. (2017) Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study. Environ Health Perspect 125:76-81
Liu, Miaomiao; Huang, Yining; Ma, Zongwei et al. (2017) Spatial and temporal trends in the mortality burden of air pollution in China: 2004-2012. Environ Int 98:75-81
Kioumourtzoglou, Marianthi-Anna; Power, Melinda C; Hart, Jaime E et al. (2017) The Association Between Air Pollution and Onset of Depression Among Middle-Aged and Older Women. Am J Epidemiol 185:801-809
Miller, Rachel L; Zhang, Hanjie; Jezioro, Jacqueline et al. (2017) Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children. Environ Res 156:619-624
Parada Jr, Humberto; Steck, Susan E; Cleveland, Rebecca J et al. (2017) Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence. Ann Epidemiol 27:208-214.e1
Lee, Joan; Kalia, Vrinda; Perera, Frederica et al. (2017) Prenatal airborne polycyclic aromatic hydrocarbon exposure, LINE1 methylation and child development in a Chinese cohort. Environ Int 99:315-320
Chen, Kai; Zhou, Lian; Chen, Xiaodong et al. (2017) Acute effect of ozone exposure on daily mortality in seven cities of Jiangsu Province, China: No clear evidence for threshold. Environ Res 155:235-241
Pei, Sen; Shaman, Jeffrey (2017) Counteracting structural errors in ensemble forecast of influenza outbreaks. Nat Commun 8:925

Showing the most recent 10 out of 906 publications