Abstract

The purpose of the Toxicokinetic Susceptibility Research Core (TSRC) is to foster collaboration and sharing of ideas, data and methods among the members in a manner that enhances existing Center projects and motivates proposals for future studies. The specific objectives of the TSRC are to: 1) Support and expand collaborative research involving the following loci: i) biomarkers of exposure and effect, ii) biologically-based modeling, and iii) hepatotoxicity, as well as research involving two or more of these areas. 2) Establish effective mechanisms for sharing ideas within and among focus groups and expanding Core membership to other relevant scientists. 3) Increase interactions with other Research and Facility Cores to foster application of sound toxicokinetic principles in study designs of Center members and affiliates.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES010126-06
Application #
7311972
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
6
Fiscal Year
2006
Total Cost
$25,223
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161
Hoffman, Kate; Stapleton, Heather M; Lorenzo, Amelia et al. (2018) Prenatal exposure to organophosphates and associations with birthweight and gestational length. Environ Int 116:248-254
Bhatt, Aadra P; Gunasekara, Dulan B; Speer, Jennifer et al. (2018) Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells. ACS Infect Dis 4:46-52
Anderson, Chelsea; Milne, Ginger L; Park, Yong-Moon Mark et al. (2018) Cardiovascular disease risk factors and oxidative stress among premenopausal women. Free Radic Biol Med 115:246-251
Butler, Eboneé N; Bensen, Jeannette T; Chen, Mengjie et al. (2018) Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors. Cancer Epidemiol Biomarkers Prev 27:67-74
Laudermilk, Lucas T; Thomas, Joseph M; Kelada, Samir N (2018) Differential Regulation of Zfp30 Expression in Murine Airway Epithelia Through Altered Binding of ZFP148 to rs51434084. G3 (Bethesda) 8:687-693
Ballantine, Jami L; Carlson, Jenna C; Ferreira Zandoná, Andrea G et al. (2018) Exploring the genomic basis of early childhood caries: a pilot study. Int J Paediatr Dent 28:217-225
Bauer, Anna E; Avery, Christy L; Shi, Min et al. (2018) A Family Based Study of Carbon Monoxide and Nitric Oxide Signalling Genes and Preeclampsia. Paediatr Perinat Epidemiol 32:1-12
Marrus, Natasha; Eggebrecht, Adam T; Todorov, Alexandre et al. (2018) Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. Cereb Cortex 28:750-763
Burbank, Allison J; Duran, Charity G; Pan, Yinghao et al. (2018) Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. J Allergy Clin Immunol 141:1231-1238.e1

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