Abstract

The goal of the Molecular Analysis Facility Core (MAFC) is to support Center members, especially those in the Pilot Projects Program and the three Translational Research focus areas (Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease), by ensuring access to analytical resources within the MAFC sub-core facilities (Biomarker Mass Spectrometry, DNA Damage, Genome Sciences, and Translational Pathology Laboratory). Support includes consultation and experimental design, routine sample analysis and training, development of novel analytical methods needed to advance research, and in-depth data analysis, integration, and interpretation. The MAFC will achieve this goal through the following four specific aims: 1) Ensure efficient operations in the MAFC sub-core facilities, upgrading instrumentation and services to meet analytical needs of UNC-CEHS members; 2) Foster a collaborative, learning environment in which MAFC personnel and UNC-CEHS investigators can develop new competencies and research collaborations; 3) Strengthen the partnership between the IHSFC, BBFC and MAFC to enhance the value of data generated in the MAFC and to assist investigators with data integration; and 4) Increase visibility and promote capabilities of the MAFC sub-cores to attract new researchers in environmental health sciences.
These aims will contribute to the overall mission of the UNC Center for Environmental Health and Susceptibility by providing consolidated and cost-effective analytical services and technical expertise to Center members.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES010126-16
Application #
9281824
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2001-04-01
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
16
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Mayne, Stephanie L; Auchincloss, Amy H; Tabb, Loni Philip et al. (2018) Associations of Bar and Restaurant Smoking Bans With Smoking Behavior in the CARDIA Study: A 25-Year Study. Am J Epidemiol 187:1250-1258
Oliver-Williams, Clare; Howard, Annie Green; Navas-Acien, Ana et al. (2018) Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. J Am Soc Hypertens 12:426-437.e9
Pace, Nelson D; Desrosiers, Tania A; Carmichael, Suzan L et al. (2018) Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies. Paediatr Perinat Epidemiol 32:90-99
Gray, Kathleen M (2018) From Content Knowledge to Community Change: A Review of Representations of Environmental Health Literacy. Int J Environ Res Public Health 15:
Orlow, Irene; Shi, Yang; Kanetsky, Peter A et al. (2018) The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival. Pigment Cell Melanoma Res 31:287-296
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol 200:2941-2956
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Herceg, Zdenko; Ghantous, Akram; Wild, Christopher P et al. (2018) Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer 142:874-882
Hoffman, Kate; Stapleton, Heather M; Lorenzo, Amelia et al. (2018) Prenatal exposure to organophosphates and associations with birthweight and gestational length. Environ Int 116:248-254
Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161

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