The Pilot Project Program is a key component of the Center of Excellence in Environmental Toxicology (CEET), The Pilot Project Program is aimed at funding new directions in environmental health research. These grants represent one vehicle by which the Center can continue to enrich, attract and support innovative research that may not be ready for direct NIH-funding, In addition, Pilot Projects can be used to fund collaborative research that may become a component of a multi-investigator award, the development of technologies that may benefit other CEET investigators, and to take the CEET into new directions. The Pilot Project Program serves to attract junior investigators and established faculty new to environmental health sciences to the CEET. The Program encourages applications that address community-based needs and can be proposed by COEC members. The Pilot Project Program also encourages applications that will seed patient and human population-based research that may require the resources of the Integrative Health Sciences Facility Core (IHSFC). This Program represents an important vehicle by which the Center can rejuvenate its membership and draw natural alliances with new faculty. The goals of the Pilot Project Program are to: ? Support career development of junior faculty in environmental health science ? Attract established investigators into environmental health science ? Develop technologies that may benefit other CEET investigators ? Fund collaborative research that may lead to multi-investigator grant applications ? Stimulate translational research themes in environmental health science ? Fund community based research projects identified by COEC members ? Fund patient and population based exposure research that will utilize the IHSFC The CEET is in its third year of funding and has awarded 14 Pilot Projects. Four of these awards were funded January 01, 2009. Of the ten Pilot Projects that have had sufficient time to provide a return on the investment, $4,085,050 in direct costs have been generated for an investment of $225,000 which is greater than 18:1. This value is deflated to 13.1: 1 if the newly funded Pilot Projects are counted. Pilot Project funding has led to 12 articles published in the scientific literature.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES013508-07
Application #
8378474
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
7
Fiscal Year
2012
Total Cost
$219,185
Indirect Cost
$79,930
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Olson, Randal S; Cava, William La; Mustahsan, Zairah et al. (2018) Data-driven advice for applying machine learning to bioinformatics problems. Pac Symp Biocomput 23:192-203
Sinclair, Wilson R; Shrimp, Jonathan H; Zengeya, Thomas T et al. (2018) Bioorthogonal pro-metabolites for profiling short chain fatty acylation. Chem Sci 9:1236-1241
Rockstrom, Matthew D; Chen, Liangyu; Taishi, Ping et al. (2018) Tumor necrosis factor alpha in sleep regulation. Sleep Med Rev 40:69-78
Portnoy, Jill; Raine, Adrian; Liu, Jianghong et al. (2018) Reductions of intimate partner violence resulting from supplementing children with omega-3 fatty acids: A randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Aggress Behav :
Cousminer, Diana L; Mitchell, Jonathan A; Chesi, Alessandra et al. (2018) Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood. J Bone Miner Res 33:430-436
Wang, Ting; Pehrsson, Erica C; Purushotham, Deepak et al. (2018) The NIEHS TaRGET II Consortium and environmental epigenomics. Nat Biotechnol 36:225-227
Panzer, Ariane R; Lynch, Susan V; Langelier, Chaz et al. (2018) Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients. Am J Respir Crit Care Med 197:621-631
Manners, M T; Yohn, N L; Lahens, N F et al. (2018) Transgenerational inheritance of chronic adolescent stress: Effects of stress response and the amygdala transcriptome. Genes Brain Behav :e12493
Fisher, Aron B; Vasquez-Medina, Jose P; Dodia, Chandra et al. (2018) Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes. Redox Biol 14:41-46
Furman, Ran; Lee, Jin V; Axelsen, Paul H (2018) Analysis of eicosanoid oxidation products in Alzheimer brain by LC-MS with uniformly 13C-labeled internal standards. Free Radic Biol Med 118:108-118

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