Excellent biomedical research is not an end in Itself, but must be judged by the impact that it has on human health, disease, death and quality of life. """"""""Translation"""""""" refers to the complex processes by which research results in tangible benefits for people. In the NIH Roadmap Initiative, it is seen as quickly transforming basic research discoveries Into drugs, treatments or methods for prevention. Translation is complex, and requires an integrated vision and a chain of disciplines that can take a discovery from the bench to the bedside successfully. Translation to decrease disease and mortality and to improve quality of life by reducing environmental exposures requires that scientific advances alter the fabric of our lives and our society. Effective translation of this type is neither routine for the biomedical research establishment or the health care delivery system. Our COEC aims to facilitate and lead translation of advances in environmental health sciences into the lives, behaviors and practices of the three NIEHS Identified target audiences;communities, health care professionals, and public and private sector decision and policy makers. Meaningful interaction with these target audiences Is bi-directional: these audiences help identify the environmental health problems that need to be solved, frame research questions, and help ensure practical application;researchers ensure that questions are answered in a scientifically rigorous and defensible way. Effective translation requires integration of COEC activities within CEET, so that there is coordinated transfer of information between basic and clinical scientists, and with the target audiences who have an interest in the results. Within CEET, translation is an integrated responsibility, and part of the vision and mission of the center. This is essential because the process of translation usually involves competencies and time commitments that are beyond the reasonable scope of any one individual, and because translation needs capabilities from various CEET components. The roles of the COEC are to develop and maintain close working relationships and partnerships with the stakeholder communities, health care professionals and decision and policy makers;to enhance two-way communication and provide education to those groups;to facilitate the dissemination of research results to target audiences;and to help bring research needs of these communities to the attention of Center researchers. Since the COEC Is proscribed from doing research it must rely on the expertise and research findings from the wet and dry research laboratories within CEET.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
United States
Zip Code
Ge, Moyar Qing; Kokalari, Blerina; Flayer, Cameron H et al. (2016) Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure. J Immunol 196:553-7
Foster, James A; Gerton, George L (2016) The Acrosomal Matrix. Adv Anat Embryol Cell Biol 220:15-33
Mor, Danielle E; Ugras, Scott E; Daniels, Malcolm J et al. (2016) Dynamic structural flexibility of α-synuclein. Neurobiol Dis 88:66-74
Moon, Edmund K; Ranganathan, Raghuveer; Eruslanov, Evgeniy et al. (2016) Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer. Clin Cancer Res 22:436-47
Guo, Lili; Shestov, Alexander A; Worth, Andrew J et al. (2016) Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem 291:42-57
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17
Adeniji, Adegoke; Uddin, Md Jashim; Zang, Tianzhu et al. (2016) Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. J Med Chem 59:7431-44
Salamatipour, Ashkan; Mohanty, Sanjay K; Pietrofesa, Ralph A et al. (2016) Asbestos Fiber Preparation Methods Affect Fiber Toxicity. Environ Sci Technol Lett 3:270-274
Mesaros, Clementina; Blair, Ian A (2016) Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteomics 13:20
Li, Yuli; Cui, Naixue; Cao, Fenglin et al. (2016) Children's Bonding with Parents and Grandparents and Its Associated Factors. Child Indic Res 9:551-564

Showing the most recent 10 out of 511 publications