The Pilot Project Program is a key component of the Center of Excellence in Environmental Toxicology (CEET), The Pilot Project Program is aimed at funding new directions in environmental health research. These grants represent one vehicle by which the Center can continue to enrich, attract and support innovative research that may not be ready for direct NIH-funding, In addition, Pilot Projects can be used to fund collaborative research that may become a component of a multi-investigator award, the development of technologies that may benefit other CEET investigators, and to take the CEET into new directions. The Pilot Project Program serves to attract junior investigators and established faculty new to environmental health sciences to the CEET. The Program encourages applications that address community-based needs and can be proposed by COEC members. The Pilot Project Program also encourages applications that will seed patient and human population-based research that may require the resources of the Integrative Health Sciences Facility Core (IHSFC). This Program represents an important vehicle by which the Center can rejuvenate its membership and draw natural alliances with new faculty. The goals of the Pilot Project Program are to: ? Support career development of junior faculty in environmental health science ? Attract established investigators into environmental health science ? Develop technologies that may benefit other CEET investigators ? Fund collaborative research that may lead to multi-investigator grant applications ? Stimulate translational research themes in environmental health science ? Fund community based research projects identified by COEC members ? Fund patient and population based exposure research that will utilize the IHSFC The CEET is in its third year of funding and has awarded 14 Pilot Projects. Four of these awards were funded January 01, 2009. Of the ten Pilot Projects that have had sufficient time to provide a return on the investment, $4,085,050 in direct costs have been generated for an investment of $225,000 which is greater than 18:1. This value is deflated to 13.1: 1 if the newly funded Pilot Projects are counted. Pilot Project funding has led to 12 articles published in the scientific literature.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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University of Pennsylvania
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Kress, Geraldine J; Liao, Fan; Dimitry, Julie et al. (2018) Regulation of amyloid-? dynamics and pathology by the circadian clock. J Exp Med 215:1059-1068
Wang, Jessica; Um, Phoebe; Dickerman, Barbra A et al. (2018) Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications. Nutrients 10:
Sanders, Alison P; Svensson, Katherine; Gennings, Chris et al. (2018) Prenatal lead exposure modifies the effect of shorter gestation on increased blood pressure in children. Environ Int 120:464-471
Bansal, Amita; Simmons, Rebecca A (2018) Epigenetics and developmental origins of diabetes: correlation or causation? Am J Physiol Endocrinol Metab 315:E15-E28
Pietryk, Edward W; Clement, Kiristin; Elnagheeb, Marwa et al. (2018) Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme. Reprod Toxicol 78:9-19
Peterson, Jennifer K; Salazar, Renzo; Castillo-Neyra, Ricardo et al. (2018) Trypanosoma cruzi Infection Does Not Decrease Survival or Reproduction of the Common Bed Bug, Cimex lectularius. Am J Trop Med Hyg 98:724-734
Guo, Lili; Wang, Qingqing; Weng, Liwei et al. (2018) Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes. Sci Rep 8:17043
Leko, Vid; Sripathy, Smitha; Adrianse, Robin L et al. (2018) Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome. J Vis Exp :
Bansal, Amita; Henao-Mejia, Jorge; Simmons, Rebecca A (2018) Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health. Endocrinology 159:32-45
Ye, Tianpeng; Cui, Naixue; Yang, Wen et al. (2018) Evaluation of the Factor Structure of the Adolescent Stress Questionnaire in Chinese Adolescents. Psychol Rep :33294118792686

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