The Systems Biology Core, directed by Eberhard Voit, is composed of an educational component and a service component. The goal of the core is to educate HERCULES investigators on how systems biology approaches can help generate data that can be used in higher-level exposome models. The service component will provide bioinformatic, biostatistical, and systems biology support for all HERCULES investigators. The Integrated Health Sciences Facility Core, directed by Dean Jones, will provide three central functions within the Center, support of clinical research services, personalized exposure surveillance using a top-down high-resolution metabolomics method and targeted exposure analysis using mass spectrometry, immunoassay and chemical sensor methods. The core will facilitate translational and clinical studies by providing access and expertise with several well-characterized human/clinical populations. The IHSFC will act at the interface of the exposome and clinical and public health practice.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Emory University
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Faraji, Mojdeh; Voit, Eberhard O (2017) Nonparametric dynamic modeling. Math Biosci 287:130-146
Jayaram, Dhanya T; Runa, Sabiha; Kemp, Melissa L et al. (2017) Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells. Nanoscale 9:7595-7601
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Fischer, S Taylor; Lili, Loukia N; Li, Shuzhao et al. (2017) Low-level maternal exposure to nicotine associates with significant metabolic perturbations in second-trimester amniotic fluid. Environ Int 107:227-234
Chen, Connie; Gribble, Matthew O; Bartroff, Jay et al. (2017) The Sequential Probability Ratio Test: An efficient alternative to exact binomial testing for Clean Water Act 303(d) evaluation. J Environ Manage 192:89-93
Ladva, Chandresh Nanji; Golan, Rachel; Greenwald, Roby et al. (2017) Metabolomic profiles of plasma, exhaled breath condensate, and saliva are correlated with potential for air toxics detection. J Breath Res 12:016008
Go, Young-Mi; Jones, Dean P (2017) Redox theory of aging: implications for health and disease. Clin Sci (Lond) 131:1669-1688
Niedzwiecki, Megan M; Miller, Gary W (2017) The Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course. Environ Health Perspect 125:064502
Dennis, Kristine K; Marder, Elizabeth; Balshaw, David M et al. (2017) Biomonitoring in the Era of the Exposome. Environ Health Perspect 125:502-510

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