The Systems Biology Core, directed by Eberhard Voit, is composed of an educational component and a service component. The goal of the core is to educate HERCULES investigators on how systems biology approaches can help generate data that can be used in higher-level exposome models. The service component will provide bioinformatic, biostatistical, and systems biology support for all HERCULES investigators. The Integrated Health Sciences Facility Core, directed by Dean Jones, will provide three central functions within the Center, support of clinical research services, personalized exposure surveillance using a top-down high-resolution metabolomics method and targeted exposure analysis using mass spectrometry, immunoassay and chemical sensor methods. The core will facilitate translational and clinical studies by providing access and expertise with several well-characterized human/clinical populations. The IHSFC will act at the interface of the exposome and clinical and public health practice.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30ES019776-02
Application #
8664390
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Panuwet, Parinya; Hunter Jr, Ronald E; D'Souza, Priya E et al. (2016) Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring. Crit Rev Anal Chem 46:93-105
Jones, Dean P (2016) Hydrogen peroxide and central redox theory for aerobic life: A tribute to Helmut Sies: Scout, trailblazer, and redox pioneer. Arch Biochem Biophys 595:13-8
Walker, Douglas I; Mallon, Col Timothy M; Hopke, Philip K et al. (2016) Deployment-Associated Exposure Surveillance With High-Resolution Metabolomics. J Occup Environ Med 58:S12-21
Sun, Yan V; Hu, Yi-Juan (2016) Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases. Adv Genet 93:147-90
Collins, Jeffrey M; Kempker, Russell R; Ziegler, Thomas R et al. (2016) Metabolomics and Mycobacterial Disease: Don't Forget the Bioinformatics. Ann Am Thorac Soc 13:141-2
Watkins, Deborah J; Fortenberry, Gamola Z; Sánchez, Brisa N et al. (2016) Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment. Environ Res 147:307-13
Rao, Anuradha; Kosters, Astrid; Mells, Jamie E et al. (2016) Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice. Sci Transl Med 8:357ra122
Jones, Dean P; Walker, Douglas I; Uppal, Karan et al. (2016) Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel. J Occup Environ Med 58:S111-6
Li, Shuzhao; Dunlop, Anne L; Jones, Dean P et al. (2016) High-Resolution Metabolomics: Review of the Field and Implications for Nursing Science and the Study of Preterm Birth. Biol Res Nurs 18:12-22
Jones, Dean P (2016) Sequencing the exposome: A call to action. Toxicol Rep 3:29-45

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