Abstract

The Systems Biology Core, directed by Eberhard Voit, is composed of an educational component and a service component. The goal of the core is to educate HERCULES investigators on how systems biology approaches can help generate data that can be used in higher-level exposome models. The service component will provide bioinformatic, biostatistical, and systems biology support for all HERCULES investigators. The Integrated Health Sciences Facility Core, directed by Dean Jones, will provide three central functions within the Center, support of clinical research services, personalized exposure surveillance using a top-down high-resolution metabolomics method and targeted exposure analysis using mass spectrometry, immunoassay and chemical sensor methods. The core will facilitate translational and clinical studies by providing access and expertise with several well-characterized human/clinical populations. The IHSFC will act at the interface of the exposome and clinical and public health practice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES019776-03
Application #
8838796
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
2016-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
3
Fiscal Year
2015
Total Cost
$177,309
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Go, Young-Mi; Fernandes, Jolyn; Hu, Xin et al. (2018) Mitochondrial network responses in oxidative physiology and disease. Free Radic Biol Med 116:31-40
Uppal, Karan; Ma, Chunyu; Go, Young-Mi et al. (2018) xMWAS: a data-driven integration and differential network analysis tool. Bioinformatics 34:701-702
Hajjar, Ihab; Hayek, Salim S; Goldstein, Felicia C et al. (2018) Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study. J Neuroinflammation 15:17
Frediani, Jennifer K; Naioti, Eric A; Vos, Miriam B et al. (2018) Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environ Health 17:6
Litzky, Julia F; Deyssenroth, Maya A; Everson, Todd M et al. (2018) Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatr Res 83:1075-1083
Hu, Xin; Chandler, Joshua D; Park, Soojin et al. (2018) Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung. Free Radic Biol Med 131:209-217
Deyssenroth, Maya A; Gennings, Chris; Liu, Shelley H et al. (2018) Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. Environ Int 120:373-381
Niedzwiecki, Megan M; Samant, Pradnya; Walker, Douglas I et al. (2018) Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics. Anal Chem 90:3786-3792
Monastero, Rebecca N; Vacchi-Suzzi, Caterina; Marsit, Carmen et al. (2018) Expression of Genes Involved in Stress, Toxicity, Inflammation, and Autoimmunity in Relation to Cadmium, Mercury, and Lead in Human Blood: A Pilot Study. Toxics 6:
Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129

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