Situated in the heart of Detroit, the Wayne State University """"""""Center for Urban Responses to Environmental Stressors"""""""" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psychosocial and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in (1) immune disorders, (2) metabolic disease, (3) cancer, and (4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

Public Health Relevance

The Wayne State University (WSU) Center for Urban Responses to Environmental Stressors (CURES) is focused on establishing a cleaner and healthier living and working environment in the city of Detroit. The CURES Center applies an integrated team approach to understand how exposure to urban environmental chemical and non-chemical stressors affects human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
1P30ES020957-01A1
Application #
8619371
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2014-06-05
Project End
2017-03-31
Budget Start
2014-06-05
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$19,088
Indirect Cost
$6,530
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Wright, A Michelle; Aldhalimi, Abir; Lumley, Mark A et al. (2016) Determinants of resource needs and utilization among refugees over time. Soc Psychiatry Psychiatr Epidemiol 51:539-49
Trimpin, Sarah; Thawoos, Shameemah; Foley, Casey D et al. (2016) Rapid high mass resolution mass spectrometry using matrix-assisted ionization. Methods 104:63-8
Arnetz, Judith E; Zhdanova, Ludmila; Arnetz, Bengt B (2016) Patient Involvement: A New Source of Stress in Health Care Work? Health Commun 31:1566-72
Rondini, Elizabeth A; Duniec-Dmuchowski, Zofia; Cukovic, Daniela et al. (2016) Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes. J Pharmacol Exp Ther 358:216-29
Senut, Marie-Claude; Zhang, Yanhua; Liu, Fangchao et al. (2016) Size-Dependent Toxicity of Gold Nanoparticles on Human Embryonic Stem Cells and Their Neural Derivatives. Small 12:631-46
Wright, A Michelle; Talia, Yousif R; Aldhalimi, Abir et al. (2016) Kidnapping and Mental Health in Iraqi Refugees: The Role of Resilience. J Immigr Minor Health :
Wu, Kai; Li, Lingzhi; Thakur, Chitra et al. (2016) Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma. Sci Rep 6:36305
Dubaisi, Sarah; Fang, Hailin; Kocarek, Thomas A et al. (2016) Transcriptional Regulation of Human Cytosolic Sulfotransferase 1C3 by Peroxisome Proliferator-Activated Receptor γ in LS180 Human Colorectal Adenocarcinoma Cells. Mol Pharmacol 90:562-569
Ghosh, Samiran; Ghosh, Santu; Tiwari, Ram C (2016) Bayesian approach for assessing non-inferiority in a three-arm trial with pre-specified margin. Stat Med 35:695-708
Rondini, Elizabeth A; Duniec-Dmuchowski, Zofia; Kocarek, Thomas A (2016) Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes. Drug Metab Dispos 44:595-604

Showing the most recent 10 out of 46 publications