The Icahn School of Medicine at Mount Sinai seeks to form a new Environmental Health Sciences Core Center, the Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures. The Center will leverage Mount Sinai's remarkable recent growth and build on their nationally and internationally recognized programs in children's environmental health. The Center's mission is to understand how environmental exposures in early life influence health, development, and risk of disease and dysfunction across the life span, in infancy, childhood, adolescence and beyond. The investigators will study the health impacts of chemical, genetic, nutritional, and social exposures and the interactions among them. Their approach will be transdisciplinary and highly translational. The investigators will combine clinical, population-based and biological research with leading-edge genetics, epigenetics, and bioinformatics in the setting of a hospital-based, urban School Of Medicine. Through their clinical and community partnerships, they will translate their research findings into evidence-based approaches for disease prevention and treatment. To focus their research, the Center will establish three Research Groups: Endocrine and Metabolic Disruption, Neuro-Immunomodulation, and Oxidant-Antioxidant Imbalance. These Research Groups will bring together basic scientists, clinicians and population scientists committed to developing new, transdisciplinary research in environmental health. The Research Groups will be supported by three Facility Cores: an Integrated Health Sciences Facility Core with sub-Cores in Exposure Biomarkers, Molecular Biomarkers, Clinical Population Access, and a Placenta Biobank;an Environmental Epidemiology, Statistics and Informatics Facility Core;and a clinically-oriented Phenotyping and Stress Assessment Facility Core. The Center supports a Pilot Project Program, a Career Development Program, and a Community Outreach and Engagement Core, committed to bidirectional communication and partnership with the diverse and disadvantaged communities that Mount Sinai serves. Mount Sinai has attracted well-funded senior faculty who will be leaders in the Center, built a strong base of NIEHS funding, constructed new laboratories, assembled multiple prospective birth cohorts, developed a successful research training fellowship in pediatric environmental health, developed a robust Pilot Project Program, gained designation as a WHO Collaborating Centre, and made significant scientific discoveries. The formation of an NIEHS Core Center will strengthen the program's identity, sustain the scientific capacity, and help build the careers of the young scientists who are our future leaders.

Public Health Relevance

The Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures will advance public health in the United States and around the world by 1) supporting state-of-the-art research that is designed to discover the environmental causes of disease and disability in children, 2) translating scientific discoveries into new, evidence-based strategies for disease prevention and treatment, and 3) building the careers of young physicians and scientists who will be our nation's future public health leaders. INSTITUTIONAL COMMITMENT AND ORGANIZATION

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
1P30ES023515-01
Application #
8619147
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
Project Start
2014-06-18
Project End
2018-03-31
Budget Start
2014-06-18
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$902,182
Indirect Cost
$369,921
Name
Icahn School of Medicine at Mount Sinai
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Gutiérrez-Avila, Iván; Rojas-Bracho, Leonora; Riojas-Rodríguez, Horacio et al. (2018) Cardiovascular and Cerebrovascular Mortality Associated With Acute Exposure to PM2.5 in Mexico City. Stroke 49:1734-1736
Parada Jr, Humberto; Gammon, Marilie D; Chen, Jia et al. (2018) Urinary Phthalate Metabolite Concentrations and Breast Cancer Incidence and Survival following Breast Cancer: The Long Island Breast Cancer Study Project. Environ Health Perspect 126:047013
Zhang, W; Li, Q; Deyssenroth, M et al. (2018) Timing of prenatal exposure to trauma and altered placental expressions of hypothalamic-pituitary-adrenal axis genes and genes driving neurodevelopment. J Neuroendocrinol 30:e12581
Lee, Alison; Leon Hsu, Hsiao-Hsien; Mathilda Chiu, Yueh-Hsiu et al. (2018) Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex. J Allergy Clin Immunol 141:1880-1886
Wahlberg, Karin; Arora, Manish; Curtin, Austen et al. (2018) Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth. Neurotoxicology 64:103-109
Curtin, Paul; Austin, Christine; Curtin, Austen et al. (2018) Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Sci Adv 4:eaat1293
Mao, Qixing; Manservisi, Fabiana; Panzacchi, Simona et al. (2018) The Ramazzini Institute 13-week pilot study on glyphosate and Roundup administered at human-equivalent dose to Sprague Dawley rats: effects on the microbiome. Environ Health 17:50
Barouki, R; Melén, E; Herceg, Z et al. (2018) Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int 114:77-86
Eick, Stephanie M; Barrett, Emily S; van 't Erve, Thomas J et al. (2018) Association between prenatal psychological stress and oxidative stress during pregnancy. Paediatr Perinat Epidemiol 32:318-326
Litzky, Julia F; Deyssenroth, Maya A; Everson, Todd M et al. (2018) Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatr Res 83:1075-1083

Showing the most recent 10 out of 289 publications