The Vision Research Division of the Jules Stein Eye Institute (JSEI) and affiliated Departments at UCLA consists of 15 vision scientists with NEI funding. The objective of the Core Grant for Vision Research at the JSEI is to provide a critically needed infrastructure to support the research activities of this talented group of scientists whose common goal is to increase basic knowledge of the visual system and its disorders. To achieve this objective, personnel and instrument support facilities are organized according to the following modules: (1) Biochemistry and Molecular Biology Instrumentation;(2) Microscopy and Imaging;(3) Machine Shop and (4) Live imaging and Functional Evaluation. These Modules provide instrumentation commonly used by multiple laboratories and are essential to the success of on-going projects as well as to enable new collaborative efforts. Purchase of state-of-the-art instruments in the modules was made possible by the generosity of the JSEI through various donors as well as recent funds from the American Recovery and Reinvestment Act. Support in the form of the Core grant is requested to maintain these Modules through instrument service contracts, and to provide necessary personnel support to assist and train users and provide routine maintenance.

Public Health Relevance

The overall goals of the Vision Science Investigators at the Jules Stein Eye Institute are to: (1) determine molecular mechanisms of visual function;(2) use that basic knowledge to understand the disease states that arise from defects (mutations) in specific proteins, and (3) explore genetic and pharmacological means of correcting these defects. Success in these endeavors will have a hriajor impact in improving vision health.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY000331-46
Application #
8426154
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
1997-03-01
Project End
2015-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
46
Fiscal Year
2013
Total Cost
$523,873
Indirect Cost
$183,696
Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Clark, Robert A; Demer, Joseph L (2016) Functional morphometry demonstrates extraocular muscle compartmental contraction during vertical gaze changes. J Neurophysiol 115:370-8
Strom, Samuel P; Clark, Michael J; Martinez, Ariadna et al. (2016) De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa. PLoS One 11:e0150944
Yulek, Fatma; Demer, Joseph L (2016) Isolated schwannoma involving extraocular muscles. J AAPOS 20:343-7
Yang, Zhongyu; Bridges, Michael D; López, Carlos J et al. (2016) A triarylmethyl spin label for long-range distance measurement at physiological temperatures using T1 relaxation enhancement. J Magn Reson 269:50-4
Demer, Joseph L (2016) Optic Nerve Sheath as a Novel Mechanical Load on the Globe in Ocular Duction. Invest Ophthalmol Vis Sci 57:1826-38
Frausto, Ricardo F; Le, Derek J; Aldave, Anthony J (2016) Transcriptomic Analysis of Cultured Corneal Endothelial Cells as a Validation for Their Use in Cell Replacement Therapy. Cell Transplant 25:1159-76
González, Sheyla; Mei, Hua; Nakatsu, Martin N et al. (2016) A 3D culture system enhances the ability of human bone marrow stromal cells to support the growth of limbal stem/progenitor cells. Stem Cell Res 16:358-64
Ingram, Norianne T; Sampath, Alapakkam P; Fain, Gordon L (2016) Why are rods more sensitive than cones? J Physiol 594:5415-26
Bui, Tina; Young, Jonathan W; Frausto, Ricardo F et al. (2016) Hereditary Benign Intraepithelial Dyskeratosis: Report of a Case and Re-examination of the Evidence for Locus Heterogeneity. Ophthalmic Genet 37:76-80
Chaudhuri, Zia; Demer, Joseph L (2016) Graded vertical rectus tenotomy for small-angle cyclovertical strabismus in sagging eye syndrome. Br J Ophthalmol 100:648-51

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