The overall objective of this core grant is enhance vision research at Yale University. By providing five key support modules, this grant will enhance the ongoing research projects of individual investigators by providing facilities and expertise that cannot be supported by individual research grants. The modules will also serve to promote and facilitate collaborative interactions between investigators and will encourage pilot projects from which specific research proposals can be developed. Finally, the modules of this core grant will serve as an invaluable resource for trainees of the Yale Visual Sciences Training Program which sponsors both pre- and postdoctoral fellows. The specific modules proposed in this application include a machine shop and a photography module, both of which serve obvious functions. A tissue culture/hybridoma module will provide complete facilities for the initiation and maintenance of small and large scale cultures of both primary cells and cell lines. It will also provide a service for production and bulk growth of monoclonal antibodies. A pharmacology/tissue preparation module will provide eye tissues and cell preparations of reproducible quality for a number of investigators. A chemistry/molecular biology module will provide and maintain specialized shared equipment such as scintillation counters, ultracentrifuges FPLC and HPLC systems. In addition it will serve as a resource for Vision Center Investigators by providing vectors and bacterial strains as well as oligonucleotides for PCR, sequencing and binding studies.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY000785-28
Application #
2888055
Study Section
Special Emphasis Panel (ZEY1-VSN (02))
Project Start
1976-08-01
Project End
2002-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
28
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Yale University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Donahue, Christopher H; Lee, Daeyeol (2015) Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex. Nat Neurosci 18:295-301
Burbridge, Timothy J; Xu, Hong-Ping; Ackman, James B et al. (2014) Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors. Neuron 84:1049-64
Ackman, James B; Crair, Michael C (2014) Role of emergent neural activity in visual map development. Curr Opin Neurobiol 24:166-75
Ribic, Adema; Liu, Xinran; Crair, Michael C et al. (2014) Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. J Comp Neurol 522:900-20
Lv, Caixia; Gould, Travis J; Bewersdorf, Joerg et al. (2012) High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy. Microsc Microanal 18:745-52
Norman-Haignere, Samuel V; McCarthy, Gregory; Chun, Marvin M et al. (2012) Category-selective background connectivity in ventral visual cortex. Cereb Cortex 22:391-402
Ackman, James B; Burbridge, Timothy J; Crair, Michael C (2012) Retinal waves coordinate patterned activity throughout the developing visual system. Nature 490:219-25
Dhande, Onkar S; Bhatt, Shivani; Anishchenko, Anastacia et al. (2012) Role of adenylate cyclase 1 in retinofugal map development. J Comp Neurol 520:1562-83
Kuhl, Brice A; Bainbridge, Wilma A; Chun, Marvin M (2012) Neural reactivation reveals mechanisms for updating memory. J Neurosci 32:3453-61
Peng, Shaomin; Gan, Geliang; Rao, Veena S et al. (2012) Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium. Invest Ophthalmol Vis Sci 53:5016-28

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