The eye and vision research group of the Medical College of Wisconsin requests continuing support for its Core program. Fourteen Core investigators from five departments on campus work on many tissues of the eye and on the visual system, with areas of research interest ranging from protein structure to brain function. Over the nearly 30 years we have received Core support we have developed and continuously updated our Core Modules so that they efficiently and equitably serve the needs of our group. In addition to helping support our individual research, we also use our Core program to bring our diverse skills together to collaborate on research questions of common interest. With rapid changes in technology and an increasing expectation for interdisciplinary research, shared resources and a mechanism to share new skills have become essential for continued research success. The goal of our Core program is therefore to enhance the independent and collaborative investigations of our participants by providing both economical infrastructural support for services that cannot be readily supported by individuals, and access to current techniques. The latter is provided by knowledgeable Module directors, experienced staff, continuously upgraded instrumentation, and a Core program that stresses integration of Module functions. Here we request ongoing support for five Modules: Animal Resource Module, Cell Culture Module, Image Analysis Module, Molecular Biology-Biochemistry Module and Morphology Module. We attribute our past success partly to the availability of our Core-supported Modules and believe that continued Core support is critical to enhancing the quality of our research and to maintaining the cohesiveness and productivity of our research group.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
3P30EY001931-35S1
Application #
8454793
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2012-06-30
Budget Start
2011-04-01
Budget End
2012-06-30
Support Year
35
Fiscal Year
2012
Total Cost
$152,601
Indirect Cost
$52,862
Name
Medical College of Wisconsin
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Kalitzeos, Angelos; Samra, Ranjit; Kasilian, Melissa et al. (2017) CELLULAR IMAGING OF THE TAPETAL-LIKE REFLEX IN CARRIERS OF RPGR-ASSOCIATED RETINOPATHY. Retina :
Baghaie, Ahmadreza; Yu, Zeyun; D'Souza, Roshan M (2017) Involuntary eye motion correction in retinal optical coherence tomography: Hardware or software solution? Med Image Anal 37:129-145
Lewis, Tylor R; Kundinger, Sean R; Pavlovich, Amira L et al. (2017) Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol 425:176-190
Vogel, Ryan N; Langlo, Christopher S; Scoles, Drew et al. (2017) High-Resolution Imaging of Intraretinal Structures in Active and Resolved Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci 58:42-49
Weh, Eric; Takeuchi, Hideyuki; Muheisen, Sanaa et al. (2017) Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. PLoS One 12:e0184903
Cunefare, David; Fang, Leyuan; Cooper, Robert F et al. (2017) Open source software for automatic detection of cone photoreceptors in adaptive optics ophthalmoscopy using convolutional neural networks. Sci Rep 7:6620
Mainali, Laxman; Raguz, Marija; O'Brien, William J et al. (2017) Changes in the Properties and Organization of Human Lens Lipid Membranes Occurring with Age. Curr Eye Res 42:721-731
Protas, Meredith E; Weh, Eric; Footz, Tim et al. (2017) Mutations of conserved non-coding elements of PITX2 in patients with ocular dysgenesis and developmental glaucoma. Hum Mol Genet 26:3630-3638
Tanna, Preena; Kasilian, Melissa; Strauss, Rupert et al. (2017) Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy. Invest Ophthalmol Vis Sci 58:3608-3615
Salmon, Alexander E; Cooper, Robert F; Langlo, Christopher S et al. (2017) An Automated Reference Frame Selection (ARFS) Algorithm for Cone Imaging with Adaptive Optics Scanning Light Ophthalmoscopy. Transl Vis Sci Technol 6:9

Showing the most recent 10 out of 486 publications