The functions of this Module have evolved over the years in response to changing technology and changing needs. At the beginning of the current cycle the 'molecular biology'component of the Module was very active, notably the Module's sequencing service. However, since sequencing is now largely outsourced and the research of our group increasingly emphasizes protein biochemistry, the functions of our Module now emphasize this activity, while maintaining some molecular biology support services. The major functions of the Module are twofold: (1) to provide access to and training in the use of shared-use instruments for biochemical and molecular analyses that are well maintained, and (2) to provide skilled technical support to facilitate access to the school's core research resources. The benefit to users of the first function include not only the consistent readiness of equipment, but also the savings in space, in training time, and in expense by avoiding unnecessary equipment duplication. Regarding the second Module function, facilitating access to institutional resources by our Core Grant was a strategic decision of the Core Advisory Committee during the current cycle (as indicated in the Overview section). This was seen as a way to increase innovation in our labs by making available state-of-the-art research instruments. It also effectively leverages our Core resources and reduces expenditures by Core investigators who want to use fee-for-service institutional cores. Additionally, it has the intangible but important benefit of integrating eye/vision scientists with the broader scientific community on campus. The Biochemistry-Molecular Biology Module specifically increases access to three MCW core resources: the Innovation Center (Mass Spectrometry Facility), the Biochemistry facility for Surface Plasmon Resonance (BIAcore 3000) analysis, and the Free Radical Research Center.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY001931-37
Application #
8502502
Study Section
Special Emphasis Panel (ZEY1-VSN)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
37
Fiscal Year
2013
Total Cost
$126,944
Indirect Cost
$43,974
Name
Medical College of Wisconsin
Department
Type
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Razeen, Moataz M; Cooper, Robert F; Langlo, Christopher S et al. (2016) Correlating Photoreceptor Mosaic Structure to Clinical Findings in Stargardt Disease. Transl Vis Sci Technol 5:6
Baghaie, Ahmadreza; D'Souza, Roshan M; Yu, Zeyun (2016) Application of Independent Component Analysis Techniques in Speckle Noise Reduction of Retinal OCT Images. Optik (Stuttg) 127:5783-5791
Mainali, Laxman; Raguz, Marija; O'Brien, William J et al. (2016) Changes in the Properties and Organization of Human Lens Lipid Membranes Occurring with Age. Curr Eye Res :1-11
Chui, Toco Yuen Ping; Pinhas, Alexander; Gan, Alexander et al. (2016) Longitudinal imaging of microvascular remodelling in proliferative diabetic retinopathy using adaptive optics scanning light ophthalmoscopy. Ophthalmic Physiol Opt 36:290-302
Scoles, Drew; Sulai, Yusufu N; Cooper, Robert F et al. (2016) PHOTORECEPTOR INNER SEGMENT MORPHOLOGY IN BEST VITELLIFORM MACULAR DYSTROPHY. Retina :
Cooper, Robert F; Lombardo, Marco; Carroll, Joseph et al. (2016) Methods for investigating the local spatial anisotropy and the preferred orientation of cones in adaptive optics retinal images. Vis Neurosci 33:E005
Zhaoping, Li; Carroll, Joseph (2016) An analytical model of the influence of cone sensitivity and numerosity on the Rayleigh match. J Opt Soc Am A Opt Image Sci Vis 33:A228-37
Brilliant, Murray H; Vaziri, Kamyar; Connor Jr, Thomas B et al. (2016) Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med 129:292-8
Scoles, Drew; Flatter, John A; Cooper, Robert F et al. (2016) ASSESSING PHOTORECEPTOR STRUCTURE ASSOCIATED WITH ELLIPSOID ZONE DISRUPTIONS VISUALIZED WITH OPTICAL COHERENCE TOMOGRAPHY. Retina 36:91-103
Widomska, Justyna; Zareba, Mariusz; Subczynski, Witold Karol (2016) Can Xanthophyll-Membrane Interactions Explain Their Selective Presence in the Retina and Brain? Foods 5:

Showing the most recent 10 out of 467 publications