The Engineering &Translational Imaging (E&TI) Module is the newly redesigned Image Analysis Module that also encompasses functions of our former Animal Resources Module. The re-development and melding of Module functions was recommended by our Core Advisory Committee to reflect the changing emphases in Module use, to take better advantage of the exceptional skills of our existing personnel, and to accommodate the research interests of new members added to our group. We consider the new Module highly innovative. We also believe it will spur innovative research because of its emphasis on technology development. This Module is expected to be unusually important for fostering collaboration between those who develop new imaging technologies and those who use them - including the clinical faculty in ophthalmology - to everyone's benefit. Our former Animal Resources Module provided shared space located within the school's animal care area that is outfitted with equipment dedicated to performing ophthalmic examinations and procedures on research animals. This essential function is retained, but moved into the E&TI Module for two compelling reasons: (1) the animal area is increasingly used for retinal imaging and functional analyses of animal eyes (rather than for procedures), which is precisely parallel to the human subjects imaging supported by the former Image Analysis Module (now renamed the E&TI), and (2) the former Animal Resource Module had no support staff. Our newly designed E&TI Module will have an expanded role for the Module assistant who aids with studies of human subjects to include studies of research animals. The Module will also have an engineer to maintain existing instruments, modify them to suit investigators'needs, and - importantly - to develop new instruments and new image processing and data analysis software. This Module staffing will bring significantly added value to those who do animal research. Further, the translational aspect of our Core investigators'research will be strongly supported by melding support for animal and human eye imaging under the same Module umbrella. The highly innovative and well integrated functions of the newly designed E&TI Module therefore are: (1) to provide engineering support for maintaining, modifying and developing novel imaging technologies, (2) to assist with generating and analyzing images of animal and human eyes, both for testing new devices and for studying ocular phenotypes, and (3) to facilitate studies involving imaging of human subjects in collaboration with clinician scientists through the services of a Module assistant who functions as clinical research coordinator. This Module is expected to significantly enhance productivity and provide important cost benefits by making available equipment and services that could not be supported on individual investigator's grants including specialized imaging instruments, an engineer skilled in working on optical devices, and a clinical research coordinator to facilitate human subjects research

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN)
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Medical College of Wisconsin
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Kalitzeos, Angelos; Samra, Ranjit; Kasilian, Melissa et al. (2017) CELLULAR IMAGING OF THE TAPETAL-LIKE REFLEX IN CARRIERS OF RPGR-ASSOCIATED RETINOPATHY. Retina :
Baghaie, Ahmadreza; Yu, Zeyun; D'Souza, Roshan M (2017) Involuntary eye motion correction in retinal optical coherence tomography: Hardware or software solution? Med Image Anal 37:129-145
Lewis, Tylor R; Kundinger, Sean R; Pavlovich, Amira L et al. (2017) Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol 425:176-190
Vogel, Ryan N; Langlo, Christopher S; Scoles, Drew et al. (2017) High-Resolution Imaging of Intraretinal Structures in Active and Resolved Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci 58:42-49
Weh, Eric; Takeuchi, Hideyuki; Muheisen, Sanaa et al. (2017) Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome. PLoS One 12:e0184903
Cunefare, David; Fang, Leyuan; Cooper, Robert F et al. (2017) Open source software for automatic detection of cone photoreceptors in adaptive optics ophthalmoscopy using convolutional neural networks. Sci Rep 7:6620
Mainali, Laxman; Raguz, Marija; O'Brien, William J et al. (2017) Changes in the Properties and Organization of Human Lens Lipid Membranes Occurring with Age. Curr Eye Res 42:721-731
Protas, Meredith E; Weh, Eric; Footz, Tim et al. (2017) Mutations of conserved non-coding elements of PITX2 in patients with ocular dysgenesis and developmental glaucoma. Hum Mol Genet 26:3630-3638
Tanna, Preena; Kasilian, Melissa; Strauss, Rupert et al. (2017) Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy. Invest Ophthalmol Vis Sci 58:3608-3615
Salmon, Alexander E; Cooper, Robert F; Langlo, Christopher S et al. (2017) An Automated Reference Frame Selection (ARFS) Algorithm for Cone Imaging with Adaptive Optics Scanning Light Ophthalmoscopy. Transl Vis Sci Technol 6:9

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