The vision science community at UC Berkeley has a long and distinguished history, having contributed many seminal discoveries in the fields of visual system development, physiology, psychophysics, and pathology. UC Berkeley vision scientists come from many academic disciplines, increasing our understanding of vision at many different levels. Our group consists of 20 CORE investigators, ranging in expertise and interest from molecular mechanisms of synaptic function to human visual perception. We request continued support for our CORE grant to ensure further success in vision research through shared resources and services. We seek funding for four modules which will support current faculty and attract new faculty to investigate the visual system. The modules are:: (1) Gene Delivery (Xiaohua Gong & John Flannery, co-directors), designed to provide molecular biology expertise and support in the use of viral vectors for delivering genes into tissues of the visual system and for creating transgenic animal models of ocular disease. (2) Microscopic Imaging (Maria Feller, director), which will apply and develop advanced imaging methods for vision research - facilitating the use of shared-access microscopes on the Berkeley Campus and customizing microscopes in the labs of participating investigators. (3) Software Development (Marty Banks, director), which will provide custom software solutions for shared use by visual system investigators using psychophysical and physiological methods. (4) Translational Research, to promote translation of scientific knowledge into clinical applications by supporting design, data collection, and data analysis of experiments involving human subjects. To build on our current strengths, the UC Berkeley Depts. of Molecular & Cell Biology, Psychology, Optometry, and the Helen Wills Neuroscience Institute have all targeted vision research as a priority area for new faculty hiring. Further demonstrating their commitment, these administrative groups and the University Administration have committed to collectively provide resources equivalent to $800,000 over the next 5 years to support the Vision Science CORE.

Public Health Relevance

The research activities supported by the Vision Science CORE grant are critical for advancing our understanding of the basic mechanisms of vision, and remain essential for our long-term goal of understanding, treating, and ultimately curing visual disorders.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY003176-35
Application #
9350344
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
1997-08-01
Project End
2018-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
35
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Tiriac, Alexandre; Smith, Benjamin E; Feller, Marla B (2018) Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation. Neuron 100:1059-1065.e4
Smith, Benjamin; Li, Jianfang; Metruccio, Matteo et al. (2018) Quantification of Bacterial Twitching Motility in Dense Colonies Using Transmitted Light Microscopy and Computational Image Analysis. Bio Protoc 8:
Gayet-Primo, Jacqueline; Yaeger, Daniel B; Khanjian, Roupen A et al. (2018) Heteromeric KV2/KV8.2 Channels Mediate Delayed Rectifier Potassium Currents in Primate Photoreceptors. J Neurosci 38:3414-3427
Piazza, Elise A; Denison, Rachel N; Silver, Michael A (2018) Recent cross-modal statistical learning influences visual perceptual selection. J Vis 18:1
Schmidt, Brian P; Sabesan, Ramkumar; Tuten, William S et al. (2018) Sensations from a single M-cone depend on the activity of surrounding S-cones. Sci Rep 8:8561
Mardinly, Alan R; Oldenburg, Ian Antón; Pégard, Nicolas C et al. (2018) Precise multimodal optical control of neural ensemble activity. Nat Neurosci 21:881-893
Wu, Yvonne T; Truong, Tan N; Tam, Connie et al. (2018) Impact of topical corticosteroid pretreatment on susceptibility of the injured murine cornea to Pseudomonas aeruginosa colonization and infection. Exp Eye Res 179:1-7
Agaoglu, Mehmet N; Sheehy, Christy K; Tiruveedhula, Pavan et al. (2018) Suboptimal eye movements for seeing fine details. J Vis 18:8
Morrie, Ryan D; Feller, Marla B (2018) A Dense Starburst Plexus Is Critical for Generating Direction Selectivity. Curr Biol 28:1204-1212.e5
Gao, Yuan; Su, John; Zhang, Yibing et al. (2018) Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease. Mucosal Immunol 11:1674-1683

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