Abstract

The objective of this proposal is to promote cooperative vision research at Wayne State University through the establishment of a Core Vision Research Group supported by a Core Vision Research Grant. The Core Vision Research Grant will establish the following centralized facilities for eye research. An electron Microscopy-Freeze Etch module; a Biochemistry module; and Electronics and Computer Engineering module, a Cell and Tissue culture module, and an Administration module. The Core Vision Research Group will enhance eye research primarily within the University and other nearbvy institutions. It will encompass studies on the cornea, lens, retina and visual connections. These studies will utilize ultrastructural, biochemical, physiological and biophysical research strategies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY004068-05
Application #
3102601
Study Section
Vision Research and Training Committee (VSN)
Project Start
1982-04-01
Project End
1987-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Carion, Thomas W; Greenwood, Matthew; Ebrahim, Abdul Shukkur et al. (2018) Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis. FASEB J 32:5026-5038
Shi, Haoshen; Berger, Elizabeth A (2018) Characterization of Site-Specific Phosphorylation of NF-?B p65 in Retinal Cells in Response to High Glucose and Cytokine Polarization. Mediators Inflamm 2018:3020675
Guest, John M; Singh, Pawan Kumar; Revankar, Sanjay G et al. (2018) Isavuconazole for Treatment of Experimental Fungal Endophthalmitis Caused by Aspergillus fumigatus. Antimicrob Agents Chemother 62:
Berkowitz, Bruce A; Podolsky, Robert H; Qian, Haohua et al. (2018) Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo. Invest Ophthalmol Vis Sci 59:5957-5964
Cui, Xinhan; Gao, Nan; Me, Rao et al. (2018) TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Invest Ophthalmol Vis Sci 59:4228-4237
Lu, Qi; Ganjawala, Tushar H; Hattar, Samer et al. (2018) A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration. Invest Ophthalmol Vis Sci 59:1288-1294
Ekanayaka, Sandamali A; McClellan, Sharon A; Peng, Xudong et al. (2018) HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice. J Ocul Pharmacol Ther :
Jiang, Youde; Liu, Li; Steinle, Jena J (2018) Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature. Mol Vis 24:727-732
Berkowitz, Bruce A (2018) Oxidative stress measured in vivo without an exogenous contrast agent using QUEST MRI. J Magn Reson 291:94-100
Shi, Haoshen; Ebrahim, Abdul S; Berger, Elizabeth A (2018) A Contrast in Pathogenic Responses between C57BL/6J and BALB/cJ Mice Using a Model of Retinal Injury. Am J Pathol 188:2717-2728

Showing the most recent 10 out of 357 publications