Funds are requested by a group of 22 vision scientists to support three research modules in the Anatomy/Cell Biology Department and one module in the Functional Genomics Center that provide central units that will facilitate and enhance vision research at Wayne State University. The modules will costeffectively enhance current research by providing this group of scientists with personnel and equipment to advance NEI-funded research with priority and secondly give opportunity for collaborative and new pilot project development. The four modules requested include: Morphology, Tissue Culture/Hybridoma/Molecular, Computer/Graphics and a new module, Genomics. The Morphology module provides for all facets of light and electron microscopy, immunofluorescence, immunochemistry, cryofixation and training of new personnel. The Tissue Culture/Hybridoma/Molecular module provides users with tissue and organ culture facilities, and shared equipment for routine molecular biological techniques and training. The Computer/Graphics module provides users capability for software access, production of publication, meeting and grant submission graphics assistance as well as image scanning and analysis and quantification of light microscopic images on personal or Core module microcomputers. The Genomics unit provides expertise in gene array technology and usage and training in the application of bioinformatics for data analysis. Each of the modules is staffed by a research assistant who is well-trained in the diverse areas of expertise required within each facility. The directorship of each module is composed of established vision scientists who have considerable expertise in the respective research field and who actively function to enhance NEI supported studies, and develop, encourage and facilitate collaborative efforts in vision research projects.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY004068-23
Application #
6858540
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Chin, Hemin R
Project Start
1982-04-01
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
23
Fiscal Year
2005
Total Cost
$325,615
Indirect Cost
Name
Wayne State University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Curtiss, Elizabeth; Jiang, Youde; Liu, Li et al. (2018) Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines. Mediators Inflamm 2018:3809092
Singh, Pawan Kumar; Khatri, Indu; Jha, Alokkumar et al. (2018) Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium. Sci Rep 8:11209
Han, Jing; Li, Yue; Liu, Xiuli et al. (2018) Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo. PLoS One 13:e0193031
Berkowitz, Bruce A; Podolsky, Robert H; Berri, Ali M et al. (2018) Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6brd10 Mice. Invest Ophthalmol Vis Sci 59:1659-1665
Jiang, Youde; Liu, Li; Steinle, Jena J (2018) miRNA15a regulates insulin signal transduction in the retinal vasculature. Cell Signal 44:28-32
Liu, Li; Patel, Paragi; Steinle, Jena J (2018) PKA regulates HMGB1 through activation of IGFBP-3 and SIRT1 in human retinal endothelial cells cultured in high glucose. Inflamm Res 67:1013-1019
Carion, Thomas W; Greenwood, Matthew; Ebrahim, Abdul Shukkur et al. (2018) Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis. FASEB J 32:5026-5038
Shi, Haoshen; Berger, Elizabeth A (2018) Characterization of Site-Specific Phosphorylation of NF-?B p65 in Retinal Cells in Response to High Glucose and Cytokine Polarization. Mediators Inflamm 2018:3020675
Guest, John M; Singh, Pawan Kumar; Revankar, Sanjay G et al. (2018) Isavuconazole for Treatment of Experimental Fungal Endophthalmitis Caused by Aspergillus fumigatus. Antimicrob Agents Chemother 62:
Berkowitz, Bruce A; Podolsky, Robert H; Qian, Haohua et al. (2018) Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo. Invest Ophthalmol Vis Sci 59:5957-5964

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