Continued support is requested for the NEI Core Center Grant in the Department of Ophthalmology at Emory University. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past Core Center grant has successfully utilized supporting collaborative vision research and service involving 32 faculty (including more than 21 NEI funded principal investigators), 16 postdoctoral fellows, six predoctoral fellows and generating over 250 publications over the past five years. The Structural Biology and Imaging Module adds immunohistochemistry, in vivo and in vitro confocal microscopy, fluoresence image analysis, in vivio flurophotomery and magnetic resonance image to the light and electron microscopy services. The Functional Genomics and Proteomics module provides services for synthetic oligonucleotides, protein sequences, PCR, laser microcapture with gene expression and flow cytometry. The Bioinformatics and Biostatistics Module will provide integrated biostatistics, bioinformatics and data management in advanced computational analysis and bioinformatics resources. The Core Modules have and will continue to enhance our research productivity by providing common centralized services to stimulate and facilitate collaborative studies between faculty an to attract other university disciplines to vision research. This Core facility also serves as a centralized vision research facility in Atlanta where faculty from Emory University, Yerkes Regional Primate Center, Georgia Institute of Technology, Georgia State University, Morehouse School of Medicine, The Veterans Administration Medical Center and the Centers for Disease Control and Prevention can undertake collaborative studies in vision research. The Core facilities also serve a role in the research projects of our pre- and postdoctoral fellows supported by our departmental NEI Training Grant (T32 EY007092-19), recently renewed for the next five years (2004-2009).

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
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Fiscal Year
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Emory University
Schools of Medicine
United States
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Micieli, Jonathan A; Newman, Nancy J; Barrow, Daniel L et al. (2017) Intracranial Aneurysms of Neuro-Ophthalmologic Relevance. J Neuroophthalmol 37:421-439
Dattilo, Michael; Biousse, Valérie; Newman, Nancy J (2017) Update on the Management of Central Retinal Artery Occlusion. Neurol Clin 35:83-100
Giangiacomo, Annette; Beck, Allen (2017) Pediatric glaucoma: review of recent literature. Curr Opin Ophthalmol 28:199-203
Weakley Jr, David R; Lynn, Michael J; Dubois, Lindreth et al. (2017) Myopic Shift 5 Years after Intraocular Lens Implantation in the Infant Aphakia Treatment Study. Ophthalmology 124:822-827
Alston, Christine I; Dix, Richard D (2017) Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3. PLoS One 12:e0171812
Yu-Wai-Man, Patrick; Newman, Nancy J (2017) Inherited eye-related disorders due to mitochondrial dysfunction. Hum Mol Genet 26:R12-R20
Dattilo, Michael; Vasseneix, Caroline; Bruce, Beau B et al. (2017) Correlation between Stereopsis and Reverse Stereopsis. Ophthalmology 124:411-413
Alston, Christine I; Dix, Richard D (2017) Reduced frequency of murine cytomegalovirus retinitis in C57BL/6 mice correlates with low levels of suppressor of cytokine signaling (SOCS)1 and SOCS3 expression within the eye during corticosteroid-induced immunosuppression. Cytokine 97:38-41
Tran, Jeffrey; Craven, Caroline; Wabner, Kathy et al. (2017) A Pharmacodynamic Analysis of Choroidal Neovascularization in a Porcine Model Using Three Targeted Drugs. Invest Ophthalmol Vis Sci 58:3732-3740
Biousse, Valérie (2017) Neuro-Ophthalmology and Stroke. J Neuroophthalmol 37:223-224

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