This P30 proposal requests funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 21 vision scientists in the Pittsburgh area. Of these, 13 are NEI funded (holding 13 R01 grants, 1 T32 grant, 1 K22 to be activated and 3 subcontracts), 3 are funded through other NIH institutes, and the remaining investigators are funded through private funding agencies. The core grant modules primarily support the NEI-funded investigators, and new investigators who are generating pilot data that will lead ultimately to NEI support. The scientific disciplines of the core grant participants include cell biology, cell signaling, virology, immunology, developmental biology, molecular genetics, neurobiology, electrophysiology, and ocular imaging technologies. The core grant modules are designed to support these scientific disciplines, and include: 1) image acquisition &analysis, 2) gene expression/proteomics, 3) hybridoma/tissue culture, 4) molecular biology, and 5) flow cytometry. All modules are centrally housed within the OVSRC on the 9th and 10th floors of the Eye and Ear Institute. For the past 20 years the Core Grant greatly enhanced vision research in the Pittsburgh area by providing cutting edge technology, facilitating the incorporation of that technology into research projects, and facilitating collaboration among scientists and physician scientists.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY008098-24
Application #
8240494
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
Project Start
1997-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
24
Fiscal Year
2012
Total Cost
$590,315
Indirect Cost
$200,668
Name
University of Pittsburgh
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kuffova, Lucia; Knickelbein, Jared E; Yu, Tian et al. (2016) High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. Invest Ophthalmol Vis Sci 57:1578-87
Kostanyan, Tigran; Sung, Kyung Rim; Schuman, Joel S et al. (2016) Glaucoma Structural and Functional Progression in American and Korean Cohorts. Ophthalmology 123:783-8
James, Andrea; Lee, Chanjae; Williams, Andre M et al. (2016) The hyaloid vasculature facilitates basement membrane breakdown during choroid fissure closure in the zebrafish eye. Dev Biol 419:262-272
Sigal, Ian A; Steele, Jessica; Drexler, Scott et al. (2016) Identifying the Palisades of Vogt in Human Ex Vivo Tissue. Ocul Surf 14:435-439
Parikh, Hardik A; Loewen, Ralitsa T; Roy, Pritha et al. (2016) Differential Canalograms Detect Outflow Changes from Trabecular Micro-Bypass Stents and Ab Interno Trabeculectomy. Sci Rep 6:34705
Funderburgh, James L; Funderburgh, Martha L; Du, Yiqin (2016) Stem Cells in the Limbal Stroma. Ocul Surf 14:113-20
Yun, Hongmin; Lathrop, Kira L; Hendricks, Robert L (2016) A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. Invest Ophthalmol Vis Sci 57:1749-56
Murphy, Matthew C; Nau, Amy C; Fisher, Christopher et al. (2016) Top-down influence on the visual cortex of the blind during sensory substitution. Neuroimage 125:932-40
Wang, Bo; Lucy, Katie A; Schuman, Joel S et al. (2016) Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk. Invest Ophthalmol Vis Sci 57:3088-92
Dong, Zachary M; Wollstein, Gadi; Schuman, Joel S (2016) Clinical Utility of Optical Coherence Tomography in Glaucoma. Invest Ophthalmol Vis Sci 57:OCT556-67

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