This P30 proposal requests funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 21 vision scientists in the Pittsburgh area. Of these, 13 are NEI funded (holding 13 R01 grants, 1 T32 grant, 1 K22 to be activated and 3 subcontracts), 3 are funded through other NIH institutes, and the remaining investigators are funded through private funding agencies. The core grant modules primarily support the NEI-funded investigators, and new investigators who are generating pilot data that will lead ultimately to NEI support. The scientific disciplines of the core grant participants include cell biology, cell signaling, virology, immunology, developmental biology, molecular genetics, neurobiology, electrophysiology, and ocular imaging technologies. The core grant modules are designed to support these scientific disciplines, and include: 1) image acquisition &analysis, 2) gene expression/proteomics, 3) hybridoma/tissue culture, 4) molecular biology, and 5) flow cytometry. All modules are centrally housed within the OVSRC on the 9th and 10th floors of the Eye and Ear Institute. For the past 20 years the Core Grant greatly enhanced vision research in the Pittsburgh area by providing cutting edge technology, facilitating the incorporation of that technology into research projects, and facilitating collaboration among scientists and physician scientists.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
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University of Pittsburgh
Schools of Medicine
United States
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Dang, Yalong; Waxman, Susannah; Wang, Chao et al. (2018) Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma. F1000Res 7:174
Romanowski, Eric G; Stella, Nicholas A; Yates, Kathleen A et al. (2018) In Vitro Evaluation of a Hypochlorous Acid Hygiene Solution on Established Biofilms. Eye Contact Lens 44 Suppl 2:S187-S191
Snyder, Adam C; Issar, Deepa; Smith, Matthew A (2018) What does scalp electroencephalogram coherence tell us about long-range cortical networks? Eur J Neurosci 48:2466-2481
Tran, Huong; Wallace, Jacob; Zhu, Ziyi et al. (2018) Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head. Invest Ophthalmol Vis Sci 59:2564-2575
Huang, Ge; Ramachandran, Suchitra; Lee, Tai Sing et al. (2018) Neural Correlate of Visual Familiarity in Macaque Area V2. J Neurosci 38:8967-8975
Garcia, Carlos J; Pericleous, Androulla; Elsayed, Mennat et al. (2018) Serralysin family metalloproteases protects Serratia marcescens from predation by the predatory bacteria Micavibrio aeruginosavorus. Sci Rep 8:14025
Kumar, Ajay; Xu, Yi; Yang, Enzhi et al. (2018) Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration. Invest Ophthalmol Vis Sci 59:3728-3738
Dang, Yalong; Waxman, Susannah; Wang, Chao et al. (2018) A porcine ex vivo model of pigmentary glaucoma. Sci Rep 8:5468
Smalianchuk, Ivan; Jagadisan, Uday K; Gandhi, Neeraj J (2018) Instantaneous Midbrain Control of Saccade Velocity. J Neurosci 38:10156-10167
Brazile, Bryn L; Hua, Yi; Jan, Ning-Jiun et al. (2018) Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams. Invest Ophthalmol Vis Sci 59:4653-4661

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