The Custom Fabrication Module provides our Participating Faculty and their laboratory staff with the resources and equipment necessary to design and build custom laboratory devices. Such custom devices, tailored to the particular needs of each experiment, can increase efficiency in existing experiments and open up possibilities for new experiments that would not be possible with commercially available devices. Vision research projects in any domain can benefit from these resources. The Custom Fabrication Module also provides training in the design and fabrication methods available to users, which can be critical in breaking down barriers of imagination as to what can be achieved with custom devices. In addition, the module provides guidance for users as they move through the stages of design, prototyping, and manufacturing of custom equipment. The goal is to enable users to rapidly move from concept to execution, and then allow them to implement their devices in an experimental setting and then revise as needed.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY008098-31
Application #
9572665
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
31
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Jan, Ning-Jiun; Sigal, Ian A (2018) Collagen fiber recruitment: A microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure. Acta Biomater 72:295-305
Yang, Bin; Jan, Ning-Jiun; Brazile, Bryn et al. (2018) Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues. J Biophotonics 11:e201700356
Bernstein, Cassidy S; Anderson, Mitchell T; Gohel, Chintan et al. (2018) The cellular bases of choroid fissure formation and closure. Dev Biol 440:137-151
Guo, Chuanyu; Zou, Jian; Wen, Yi et al. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience 3:63-85
Jeon, Sohyun; Rowe, Alexander M; Carroll, Kate L et al. (2018) PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1-Infected Corneas. J Immunol 200:3711-3719
Vinci, Giuseppe; Ventura, Valérie; Smith, Matthew A et al. (2018) Adjusted regularization of cortical covariance. J Comput Neurosci 45:83-101
Fu, Jinling; Nagashima, Mikiko; Guo, Chuanyu et al. (2018) Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes. Invest Ophthalmol Vis Sci 59:505-518
Chen, Yuanyuan; Chen, Yu; Jastrzebska, Beata et al. (2018) A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun 9:1976
Ni, A M; Ruff, D A; Alberts, J J et al. (2018) Learning and attention reveal a general relationship between population activity and behavior. Science 359:463-465
Jan, Ning-Jiun; Brazile, Bryn L; Hu, Danielle et al. (2018) Crimp around the globe; patterns of collagen crimp across the corneoscleral shell. Exp Eye Res 172:159-170

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