Since our initial Core Grant award in 1997 and its renewals in 2002 and 2007, this grant has played a major role in the growth of individual investigator programs, inter-departmental collaborations, and recruitment of new investigators to the visual sciences from external universities and from other departments at Case Western Reserve University (CWRU). The 2007-2012 funding cycle of the CWRU Visual Sciences Research Center (VSRC) Core Grant generated 105 publications in the areas of: 1) retinal biology and retinal degenerative and hereditary diseases;2) ocular diseases as a consequence of aging and diabetes;and 3) ocular immunology, inflammation and infectious diseases. In the current renewal, there are 11 investigators with 16 active NEI R01 grants in the Departments of Pharmacology (Palczewski, Imanishi, von Lintig), Medicine (Kern, Subauste), Chemistry (Salomon), Ophthalmology (Park, Pearlman), Pathology (Monnier), and Pediatrics (Gubitosi-Klug). There are 2 additional ROIs with very competitive scores, but have not been funded at the time of submission (Reitsch, Microbiology, and Pikuleva, Ophthalmology) and another 6 VSRC investigators with non-R01 NEI funding or no-cost extensions who utilize the Core Modules. Institutional commitment to the VSRC has been and continues to be very strong in terms of renovations, recruitment and salary support for the module managers. The modules in the 2007-2012 funding period were: 1) Tissue Culture and Hybridoma, 2) Histology, Microscopy and Imaging, 3) Molecular Biology, 4) Specialized Animal Resource, and 5) Proteomics. The two major changes to the modules in the current submission are: first, we have expanded the Specialized Animal Resource to include a small animal visual function and non-invasive retinal imaging sub-module. This sub-module will provide expertise in and use of two electroretinograms (ERG), two Scanning Laser Ophthalmoscopes, and Optical Coherence Tomography equipment, and an Optomotor that records eye movement. Second, we are not requesting renewal of the Proteomics module. Although this module was heavily utilized, it was mostly by two or three investigators;however, all of the Proteomics services remain available.
The P-30 grant provides essential technical, equipment and service support for 11 NEI funded investigators who study blinding diseases of the cornea, lens and retina of the mammalian eye. By providing these critical functions, the grant will greatly enhance the ability of these investigators to understand these diseases and can develop new therapies for corneal infections, cataract, diabetes and retinal degenerative diseases.
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|Rakshit, Tatini; Senapati, Subhadip; Parmar, Vipul M et al. (2017) Adaptations in rod outer segment disc membranes in response to environmental lighting conditions. Biochim Biophys Acta 1864:1691-1702|
|Salomon, Robert G (2017) Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products. Chem Res Toxicol 30:105-113|
|Kiser, Philip D; Zhang, Jianye; Badiee, Mohsen et al. (2017) Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther 362:131-145|
|Akeson, Graham; Malemud, Charles J (2017) A Role for Soluble IL-6 Receptor in Osteoarthritis. J Funct Morphol Kinesiol 2:|
|Lindborg, Jane A; Mack, Matthias; Zigmond, Richard E (2017) Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration. J Neurosci 37:10258-10277|
|Johansen, Mette L; Gao, Ying; Hutnick, Melanie A et al. (2017) Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo. Anal Chem 89:5932-5939|
|Tonade, Deoye; Liu, Haitao; Palczewski, Krzysztof et al. (2017) Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia 60:2111-2120|
|Afshari, Natalie A; Igo Jr, Robert P; Morris, Nathan J et al. (2017) Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun 8:14898|
|Mamidi, Ranganath; Li, Jiayang; Gresham, Kenneth S et al. (2017) Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium. Circ Heart Fail 10:|
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