This application seeks continued support for a Vision Core Grant that has facilitated the research efforts of vision scientists at the University California, Davis for the past ten years. During the decade that the CORE has been funded there has been remarkable growth in the visual sciences on this campus. This is demonstrated by a substantial increase in the number of faculty engaged in vision research as well as NEI funded grants. Since the last competitive renewal, the administration has approved the establishment and funding of a Center for Visual Sciences, which provides a means for unifying our community of vision researchers. Building on this strength, we have redesigned the currently funded four modules to better serve the needs of our NEI funded investigators. The proposed modules are: (i) Software Engineering (W. Martin Usrey, Director), (ii) Histology and Phenotype (Paul FitzGerald, Director), (iii) Retinal Anatomy and Physiology (Andrew Ishida, Director), and (iv) Instrumentation (John S. Werner, Director). These four modules provide facilities and services of greatest benefit to the largest number of our vision scientists. The CORE administrative structure includes an Advisory Committee comprised of the Principal Investigator, the four module directors, the director of the Center for Visual Sciences, as well as the Chair and research director of the Department of Ophthalmology &Vision Science. Issues involving CORE facilities and usage are discussed at quarterly meeting of the Vision Science Research Group that includes all members of our vision science community. Priorities for use of CORE facilities have been carefully honed and made available to all investigators, and this has mitigated potential scheduling conflicts. The administration of UC Davis has been and continues to be very supportive of vision research. This is demonstrated by the funding of the Center for Visual Sciences, the addition of five ophthalmology research faculties, resulting in the recent name change to Ophthalmology &Vision Science, the generous start-up packages for new vision faculty, and a pledge of more than $180,000 for equipment needs for CORE facilities during the next grant period.

Public Health Relevance

The four CORE modules are designed to effectively enhance our understanding of basic mechanisms of vision and for furthering collaborations among vision researchers and our clinical faculty. Our collective long-term objective remains the development of better treatments for dealing with the myriad disorders of the visual system.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Schools of Medicine
United States
Zip Code
Smit-McBride, Zeljka; Forward, Krisztina I; Nguyen, Anthony T et al. (2014) Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Mol Vis 20:1569-78
Murphy, Kaitlin C; Morgan, Joshua T; Wood, Joshua A et al. (2014) The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption. Exp Cell Res 328:164-71
Morgan, Joshua T; Raghunathan, Vijay Krishna; Thomasy, Sara M et al. (2014) Robust and artifact-free mounting of tissue samples for atomic force microscopy. Biotechniques 56:40-2
Smarandache-Wellmann, Carmen; Weller, Cynthia; Mulloney, Brian (2014) Mechanisms of coordination in distributed neural circuits: decoding and integration of coordinating information. J Neurosci 34:793-803
Garland, Shaun P; McKee, Clayton T; Chang, Yow-Ren et al. (2014) A cell culture substrate with biologically relevant size-scale topography and compliance of the basement membrane. Langmuir 30:2101-8
Chang, Yow-Ren; Raghunathan, Vijay Krishna; Garland, Shaun P et al. (2014) Automated AFM force curve analysis for determining elastic modulus of biomaterials and biological samples. J Mech Behav Biomed Mater 37:209-18
Thomasy, Sara M; Raghunathan, Vijay Krishna; Winkler, Moritz et al. (2014) Elastic modulus and collagen organization of the rabbit cornea: epithelium to endothelium. Acta Biomater 10:785-91
Manthey, Abby L; Lachke, Salil A; FitzGerald, Paul G et al. (2014) Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev 131:86-110
Gorouhi, Farzam; Shah, Nihar M; Raghunathan, Vijay Krishna et al. (2014) Epidermal growth factor-functionalized polymeric multilayer films: interplay between spatial location and bioavailability of EGF. J Invest Dermatol 134:1757-60
Garland, Shaun P; Wang, Royal Y; Raghunathan, Vijay Krishna et al. (2014) Photopatternable and photoactive hydrogel for on-demand generation of hydrogen peroxide in cell culture. Biomaterials 35:1762-70

Showing the most recent 10 out of 155 publications