This application seeks continued support for a Vision Core Grant that has facilitated the research efforts of vision scientists at the University California, Davis for the past ten years. During the decade that the CORE has been funded there has been remarkable growth in the visual sciences on this campus. This is demonstrated by a substantial increase in the number of faculty engaged in vision research as well as NEI funded grants. Since the last competitive renewal, the administration has approved the establishment and funding of a Center for Visual Sciences, which provides a means for unifying our community of vision researchers. Building on this strength, we have redesigned the currently funded four modules to better serve the needs of our NEI funded investigators. The proposed modules are: (i) Software Engineering (W. Martin Usrey, Director), (ii) Histology and Phenotype (Paul FitzGerald, Director), (iii) Retinal Anatomy and Physiology (Andrew Ishida, Director), and (iv) Instrumentation (John S. Werner, Director). These four modules provide facilities and services of greatest benefit to the largest number of our vision scientists. The CORE administrative structure includes an Advisory Committee comprised of the Principal Investigator, the four module directors, the director of the Center for Visual Sciences, as well as the Chair and research director of the Department of Ophthalmology &Vision Science. Issues involving CORE facilities and usage are discussed at quarterly meeting of the Vision Science Research Group that includes all members of our vision science community. Priorities for use of CORE facilities have been carefully honed and made available to all investigators, and this has mitigated potential scheduling conflicts. The administration of UC Davis has been and continues to be very supportive of vision research. This is demonstrated by the funding of the Center for Visual Sciences, the addition of five ophthalmology research faculties, resulting in the recent name change to Ophthalmology &Vision Science, the generous start-up packages for new vision faculty, and a pledge of more than $180,000 for equipment needs for CORE facilities during the next grant period.

Public Health Relevance

The four CORE modules are designed to effectively enhance our understanding of basic mechanisms of vision and for furthering collaborations among vision researchers and our clinical faculty. Our collective long-term objective remains the development of better treatments for dealing with the myriad disorders of the visual system.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (08))
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Liberman, Ellen S
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University of California Davis
Schools of Medicine
United States
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Cua, Michelle; Wahl, Daniel J; Zhao, Yuan et al. (2016) Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging. Sci Rep 6:32223
Gorczynska, Iwona; Migacz, Justin V; Zawadzki, Robert J et al. (2016) Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid. Biomed Opt Express 7:911-42
Shen, Yunyun; Pfluger, Trisha; Ferreira, Fernando et al. (2016) Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing. Sci Rep 6:26525
Thomasy, Sara M; Cortes, Dennis E; Hoehn, Alyssa L et al. (2016) In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci 57:OCT495-503
Jian, Yifan; Lee, Sujin; Ju, Myeong Jin et al. (2016) Lens-based wavefront sensorless adaptive optics swept source OCT. Sci Rep 6:27620
Thomasy, Sara M; Eaton, J Seth; Timberlake, Matthew J et al. (2016) Species Differences in the Geometry of the Anterior Segment Differentially Affect Anterior Chamber Cell Scoring Systems in Laboratory Animals. J Ocul Pharmacol Ther 32:28-37
Strom, Ann R; Cortés, Dennis E; Rasmussen, Carol A et al. (2016) In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry. Vet Ophthalmol 19:50-6
Smit-McBride, Zeljka; Moisseiev, Elad; Modjtahedi, Sara P et al. (2016) Comparison of In Vivo Gene Expression Profiling of RPE/Choroid following Intravitreal Injection of Dexamethasone and Triamcinolone Acetonide. J Ophthalmol 2016:9856736
Sebbag, Lionel; Reilly, Christopher M; Eid, Ramzi et al. (2016) Goblet cell density and distribution in cats with clinically and histologically normal conjunctiva. Vet Ophthalmol 19 Suppl 1:38-43
Strom, Ann R; Cortés, Dennis E; Thomasy, Sara M et al. (2016) In vivo ocular imaging of the cornea of the normal female laboratory beagle using confocal microscopy. Vet Ophthalmol 19:63-7

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