Research Plan Vision science experiments are becoming increasingly complex with tremendous demands being placed on interfacing specialized pieces of equipment, executing moment-by-moment dynamic control over stimulus delivery and data acquisition, and performing real-time analysis on streaming data. In addition, the increasing use of multielectrode recording systems and high-resolution imaging of neuronal morphology and activity has forced laboratories to consider the handling, storage, and computing requirements that these large datasets require. To meet these needs, the Software Engineering Core provides professional programming services to NEI funded laboratories that could not be supported by individual R01 awards. Moreover, by meeting the research needs of the faculty with a common resource, software can be engineered with the overarching goal of increasing data sharing and collaboration. Indeed, almost all of the applications and resources provided thus far are shared between multiple Core faculty, and numerous applications have been provided to NEI-funded investigators at other universities, including Dartmouth Medical School, University of California, Berkeley, University of Southern California, University of Pennsylvania, Mount Sinai School of Medicine, and Louisiana State University Medical School. The Software Engineering Core also published highly innovative software tools in a peer-reviewed journal for the broader vision science community.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
2P30EY012576-16
Application #
8884805
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
City
Davis
State
CA
Country
United States
Zip Code
95618
Smit-McBride, Zeljka; Forward, Krisztina I; Nguyen, Anthony T et al. (2014) Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye. Mol Vis 20:1569-78
Murphy, Kaitlin C; Morgan, Joshua T; Wood, Joshua A et al. (2014) The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption. Exp Cell Res 328:164-71
Morgan, Joshua T; Raghunathan, Vijay Krishna; Thomasy, Sara M et al. (2014) Robust and artifact-free mounting of tissue samples for atomic force microscopy. Biotechniques 56:40-2
Smarandache-Wellmann, Carmen; Weller, Cynthia; Mulloney, Brian (2014) Mechanisms of coordination in distributed neural circuits: decoding and integration of coordinating information. J Neurosci 34:793-803
Garland, Shaun P; McKee, Clayton T; Chang, Yow-Ren et al. (2014) A cell culture substrate with biologically relevant size-scale topography and compliance of the basement membrane. Langmuir 30:2101-8
Chang, Yow-Ren; Raghunathan, Vijay Krishna; Garland, Shaun P et al. (2014) Automated AFM force curve analysis for determining elastic modulus of biomaterials and biological samples. J Mech Behav Biomed Mater 37:209-18
Thomasy, Sara M; Raghunathan, Vijay Krishna; Winkler, Moritz et al. (2014) Elastic modulus and collagen organization of the rabbit cornea: epithelium to endothelium. Acta Biomater 10:785-91
Manthey, Abby L; Lachke, Salil A; FitzGerald, Paul G et al. (2014) Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev 131:86-110
Gorouhi, Farzam; Shah, Nihar M; Raghunathan, Vijay Krishna et al. (2014) Epidermal growth factor-functionalized polymeric multilayer films: interplay between spatial location and bioavailability of EGF. J Invest Dermatol 134:1757-60
Garland, Shaun P; Wang, Royal Y; Raghunathan, Vijay Krishna et al. (2014) Photopatternable and photoactive hydrogel for on-demand generation of hydrogen peroxide in cell culture. Biomaterials 35:1762-70

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