The long-term objective of this application is to support current and future vision research endeavors at Indiana University, Bloomington. This infrastructure grant provides support for three shared resource modules: electronics, machine shop and scientific computing. The modules will expand the seamless integration of mechanical, electronics and software components in custom research equipment and new clinical technology, plus provide new coordination of activity across numerous inter-related laboratories and a sustained interaction with sophisticated supercomputing and 3D visualization resources on campus. The applications to our vision research projects are broad, including microscopic and ocular fluorimetry, cell physiology and molecular biology, advanced measurement and modeling of the optics of the eye. Novel imaging of the structures of the normal and pathological living human eye, studies of the normal and abnormal developing human visual system, and the development of new quantitative strategies to assess visual function in a clinical setting. The local research environment has expanded to include seven new active laboratories during the past eight years and at least three more are anticipated in the next three years.

Public Health Relevance

The proposed Core Grant supports the Research activities of the Indiana University Bloomington Vision Science community. This will support research ranging from control of development of eyes, to clinical applications of imaging and image formation in the eye.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
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Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Liberman, Ellen S
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Indiana University Bloomington
Schools of Optometry/Ophthalmol
United States
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Kurokawa, Kazuhiro; Liu, Zhuolin; Miller, Donald T (2017) Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris [Invited]. Biomed Opt Express 8:1803-1822
Price, Derek A; Swanson, William H; Horner, Douglas G (2017) Using perimetric data to estimate ganglion cell loss for detecting progression of glaucoma: a comparison of models. Ophthalmic Physiol Opt 37:409-419
Liu, Tao; Thibos, Larry N (2017) Compensation of corneal oblique astigmatism by internal optics: a theoretical analysis. Ophthalmic Physiol Opt 37:305-316
Liu, Tao; Thibos, Larry N (2017) Variation of axial and oblique astigmatism with accommodation across the visual field. J Vis 17:24
Sawides, Lucie; Sapoznik, Kaitlyn A; de Castro, Alberto et al. (2017) Alterations to the Foveal Cone Mosaic of Diabetic Patients. Invest Ophthalmol Vis Sci 58:3395-3403
Zhang, Wenlin; Li, Hongde; Ogando, Diego G et al. (2017) Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium. EBioMedicine 16:292-301
Alhamami, Mastour A; Elsner, Ann E; Malinovsky, Victor E et al. (2017) Comparison of Cysts in Red and Green Images for Diabetic Macular Edema. Optom Vis Sci 94:137-149
Sawides, Lucie; de Castro, Alberto; Burns, Stephen A (2017) The organization of the cone photoreceptor mosaic measured in the living human retina. Vision Res 132:34-44
Troyer, Mary E; Sreenivasan, Vidhyapriya; Peper, T J et al. (2017) The heterophoria of 3-5 year old children as a function of viewing distance and target type. Ophthalmic Physiol Opt 37:7-15
King, Brett J; Sapoznik, Kaitlyn A; Elsner, Ann E et al. (2017) SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation. Optom Vis Sci 94:411-422

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