A Core Center Grant is proposed to support vision research at the University of Texas Southwestern Medical Center. Investigators in the Department of Ophthalmology recently completed a 5-year infrastructure grant (R24) that supported ocular surface research on our campus. The infrastructure grant was enormously successful and fostered new collaborations and culminated in 69 publications in peer-review journals. We recently received a one-year P30 Core Grant through the ARRA. This unique one-year award has fostered further collaborations among vision researchers from the Departments of Ophthalmology, Psychiatry, Physiology, Neuroscience, and the Center for Developmental Biology at the University of Texas Southwestern Medical Center. We have also initiated a number of vision-related projects and seminar series that have enriched vision research activities on this campus. This, along with the acquisition of additional NEl-supported research, prompted us to submit a 5-year P30 Core Grant application to enhance and expand research efforts that rely on three common technologies: 1) tissue culture/hybridoma;2) imaging;and 3) protein biochemistry and virus-mediated gene transfer. Significant institutional support in the form of additional laboratory space, endowed scholars'awards, and intramural research awards has provided a fertile ground for expansion and enhancement of vision research on our campus. The proposed Core Grant for Vision Research will further this effort and enhance vision research at the University of Texas Southwestern Medical Center.
We anticipate three tangible benefits from this core grant: 1) vision scientists at U.T. Southwestern Medical Center will have more and scientifically stronger publications;2) the number of vision science investigators at U.T. Southwestern Medical Center will increase;and 3) the quantity and quality of visual science graduate students and postdocs at U.T. Southwestern Medical Center will increase.
|Akbar, Mohammed Ali; Mandraju, Rajakumar; Tracy, Charles et al. (2016) ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination. Immunity 45:267-79|
|Ligocki, Ann J; Brown, Joseph R; Niederkorn, Jerry Y (2016) Role of interferon-Î³ and cytotoxic T lymphocytes in intraocular tumor rejection. J Leukoc Biol 99:735-47|
|Simmons, Ken T; Xiao, Yangyan; Pflugfelder, Stephen C et al. (2016) Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci 57:2443-51|
|Cunnusamy, Khrishen; Bowman, Charles B; Beebe, Walter et al. (2016) Congenital Corneal Endothelial Dystrophies Resulting From Novel De Novo Mutations. Cornea 35:281-5|
|Zhong, Xin; Aredo, Bogale; Ding, Yi et al. (2016) Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis. Invest Ophthalmol Vis Sci 57:5558-5567|
|Zadoo, Serena; Nguyen, Annie; Zode, Gulab et al. (2016) A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture. Invest Ophthalmol Vis Sci 57:1939-50|
|Ligocki, Ann J; Niederkorn, Jerry Y (2016) Natural Killer T Cells Contribute to Neutrophil Recruitment and Ocular Tissue Damage in a Model of Intraocular Tumor Rejection. Invest Ophthalmol Vis Sci 57:813-23|
|Butovich, Igor A; McMahon, Anne; Wojtowicz, Jadwiga C et al. (2016) Dissecting lipid metabolism in meibomian glands of humans and mice: An integrative study reveals a network of metabolic reactions not duplicated in other tissues. Biochim Biophys Acta 1861:538-53|
|Truong, David T; Bui, Minh-Thuy; Cavanagh, H Dwight (2016) Epidemiology and Outcome of Microbial Keratitis: Private University Versus Urban Public Hospital Care. Eye Contact Lens :|
|Coursey, Terry G; Tukler Henriksson, Johanna; Barbosa, Flavia L et al. (2016) Interferon-Î³-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in SjÃ¶gren Syndrome. Am J Pathol 186:1547-58|
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