Abstract

Ocular Imaging Module The Ocular Imaging Module will provide a variety of imaging modalities to the investigators involved in this P30 Core Grant for Vision Research. The module includes live animal (in vivo) imaging with slit lamp and fundus photography, scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT). It also supports tissue and cellular imaging (ex vivo) support, providing routine and specialized tissue fixation techniques, paraffin and plastic tissue embedding, sectioning (paraffin and Cryo) and staining for immunohistochemistry. Microscope imaging techniques include bright field, dark field, differential interference contrast (DIC), fluorescence, and transmission electron microscopy (TEM). It also provides help and advice with the morphometric analysis of generated images. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
1P30EY025585-01A1
Application #
9153316
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
1
Fiscal Year
2016
Total Cost
$327,367
Indirect Cost
$120,826

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243
Zhang, Lingjun; Li, Yan; Qiu, Wen et al. (2018) Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun 90:84-93
Orban, Tivadar; Leinonen, Henri; Getter, Tamar et al. (2018) A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther 364:207-220
Zhao, Yue; Chundury, Rao V; Blandford, Alexander D et al. (2018) Anatomical Description of Zygomatic Foramina in African American Skulls. Ophthalmic Plast Reconstr Surg 34:168-171
Tarchick, Matthew J; Cutler, Alecia H; Trobenter, Timothy D et al. (2018) Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes. Exp Eye Res 180:63-74
Kiser, Philip D; Zhang, Jianye; Sharma, Aditya et al. (2018) Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol 150:571-590
Blandford, Alexander D; Cherfan, Daniel G; Drake, Richard L et al. (2018) Continuous Positive Airway Pressure Thresholds for Nasolacrimal Air Regurgitation in a Cadaveric Model. Ophthalmic Plast Reconstr Surg 34:440-442
Medeiros, Carla S; Lassance, Luciana; Saikia, Paramananda et al. (2018) Posterior stromal cell apoptosis triggered by mechanical endothelial injury and basement membrane component nidogen-1 production in the cornea. Exp Eye Res 172:30-35
Kinoshita, Junzo; Peachey, Neal S (2018) Noninvasive Electroretinographic Procedures for the Study of the Mouse Retina. Curr Protoc Mouse Biol 8:1-16
Pollock, Lana M; Xie, Jing; Bell, Brent A et al. (2018) Retinoic acid signaling is essential for maintenance of the blood-retinal barrier. FASEB J 32:5674-5684

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