The purpose of the Experimental Design, Biostatistics, and Data Services (EBD) Core is to provide centralized research and statistical design, data analysis, and data management services to research supported by the Center for Alaska Native Health Research (CANHR). The EBD Core must address three issues that arise because CANHR work is based in community-based participatory research (CBPR) models and in Alaska Native settings. Research conducted by CANHR scientists is characterized by (1) qualitative as well as quantitative research designs, (2) analyses that often involve small sample longitudinal studies, and (3) research that is responsive to our CBPR partners. Community partners have expressed strong support for collaborative development of intervention studies addressing ongoing Alaska Native health issues of importance to them and that form the thematic disease focus of CANHR. Within the area of experimental and statistical design, the EBD Core will provide consultation to CANHR investigators proposing basic, applied, and intervention research projects. In addition, this work includes cross-cultural adaptation and development of measurement instruments, interview protocols, and designs for qualitative studies. The EBD Core will provide intensive consultation on statistical and qualitative analysis for CANHR research projects. These services will include both design and implementation of statistical analyses. Finally, the EBD Core will provide crucial data management services. These will include ongoing maintenance of several existing CANHR project databases, development of new databases to support future projects, and data access and reporting services. The EBD Core has the following three specific aims:
Specific Aim 1. Support the design of experimental, quasi-experimental, observational, and qualitative studies.
Specific Aim 2. Support the planning, development, and implementation of data analyses.
Specific Aim 3. Develop and maintain research databases.

Public Health Relevance

High quality experimental design, analytic, and data management services are crucial to the conduct of research conducted by CANHR. The EBD Core will provide these services to advance CANHR's CBPR model of collaborative inquiry with Alaska Native communities. These services will build capacity and sustain interdisciplinary CBPR and health disparities research projects to improve the health of Alaska Native people.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B)
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University of Alaska Fairbanks
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Ware, Desirae N; Lewis, Johnnye; Hopkins, Scarlett et al. (2014) Household reporting of childhood respiratory health and air pollution in rural Alaska Native communities. Int J Circumpolar Health 73:1-10
Ryman, Tove K; Austin, Melissa A; Hopkins, Scarlett et al. (2014) Using exploratory factor analysis of FFQ data to identify dietary patterns among Yup'ik people. Public Health Nutr 17:510-8
Klimentidis, Yann C; Lemas, Dominick J; Wiener, Howard H et al. (2014) CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people. J Diabetes 6:251-9
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O'Brien, Diane M; Kristal, Alan R; Nash, Sarah H et al. (2014) A stable isotope biomarker of marine food intake captures associations between n-3 fatty acid intake and chronic disease risk in a Yup'ik study population, and detects new associations with blood pressure and adiponectin. J Nutr 144:706-13
Howard, Barbara V; Metzger, Jesse S; Koller, Kathryn R et al. (2014) All-cause, cardiovascular, and cancer mortality in western Alaska Native people: western Alaska Tribal Collaborative for Health (WATCH). Am J Public Health 104:1334-40
Aslibekyan, Stella; Wiener, Howard W; Havel, Peter J et al. (2014) DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. J Nutr 144:425-30
Ayunerak, Paula; Alstrom, Deborah; Moses, Charles et al. (2014) Yup'ik culture and context in Southwest Alaska: community member perspectives of tradition, social change, and prevention. Am J Community Psychol 54:91-9
Allen, James; Mohatt, Gerald V; Fok, Carlotta Ching Ting et al. (2014) A protective factors model for alcohol abuse and suicide prevention among Alaska Native youth. Am J Community Psychol 54:125-39
Gonzalez, John; Trickett, Edison J (2014) Collaborative measurement development as a tool in CBPR: measurement development and adaptation within the cultures of communities. Am J Community Psychol 54:112-24

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