The purpose of the Experimental Design, Biostatistics, and Data Services (EBD) Core is to provide centralized research and statistical design, data analysis, and data management services to research supported by the Center for Alaska Native Health Research (CANHR). The EBD Core must address three issues that arise because CANHR work is based in community-based participatory research (CBPR) models and in Alaska Native settings. Research conducted by CANHR scientists is characterized by (1) qualitative as well as quantitative research designs, (2) analyses that often involve small sample longitudinal studies, and (3) research that is responsive to our CBPR partners. Community partners have expressed strong support for collaborative development of intervention studies addressing ongoing Alaska Native health issues of importance to them and that form the thematic disease focus of CANHR. Within the area of experimental and statistical design, the EBD Core will provide consultation to CANHR investigators proposing basic, applied, and intervention research projects. In addition, this work includes cross-cultural adaptation and development of measurement instruments, interview protocols, and designs for qualitative studies. The EBD Core will provide intensive consultation on statistical and qualitative analysis for CANHR research projects. These services will include both design and implementation of statistical analyses. Finally, the EBD Core will provide crucial data management services. These will include ongoing maintenance of several existing CANHR project databases, development of new databases to support future projects, and data access and reporting services. The EBD Core has the following three specific aims:
Specific Aim 1. Support the design of experimental, quasi-experimental, observational, and qualitative studies.
Specific Aim 2. Support the planning, development, and implementation of data analyses.
Specific Aim 3. Develop and maintain research databases.
High quality experimental design, analytic, and data management services are crucial to the conduct of research conducted by CANHR. The EBD Core will provide these services to advance CANHR's CBPR model of collaborative inquiry with Alaska Native communities. These services will build capacity and sustain interdisciplinary CBPR and health disparities research projects to improve the health of Alaska Native people.
|Lemas, Dominick J; Klimentidis, Yann C; Aslibekyan, Stella et al. (2016) Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Mol Nutr Food Res 60:2642-2653|
|Fohner, Alison E; Wang, Zhican; Yracheta, Joseph et al. (2016) Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska. J Nutr 146:318-25|
|Philip, Jacques; Ford, Tara; Henry, David et al. (2016) Relationship of Social Network to Protective Factors in Suicide and Alcohol Use Disorder Intervention for Rural Yup'ik Alaska Native Youth. Interv Psicosoc 25:45-54|
|O'Brien, Diane M; Thummel, Kenneth E; Bulkow, Lisa R et al. (2016) Declines in traditional marine food intake and vitamin D levels from the 1960s to present in young Alaska Native women. Public Health Nutr :1-8|
|Vaughan, Laura Kelly; Wiener, Howard W; Aslibekyan, Stella et al. (2015) Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism 64:689-97|
|Fok, Carlotta Ching Ting; Henry, David; Allen, James (2015) Research Designs for Intervention Research with Small Samples II: Stepped Wedge and Interrupted Time-Series Designs. Prev Sci 16:967-77|
|Beaulieu-Jones, Brendin R; O'Brien, Diane M; Hopkins, Scarlett E et al. (2015) Sex, Adiposity, and Hypertension Status Modify the Inverse Effect of Marine Food Intake on Blood Pressure in Alaska Native (Yup'ik) People. J Nutr 145:931-8|
|Henry, David; Fok, Carlotta Ching Ting; Allen, James (2015) Why Small is Too Small a Term: Prevention Science for Health Disparities, Culturally Distinct Groups, and Community-Level Intervention. Prev Sci 16:1026-32|
|Ryman, Tove K; Boyer, Bert B; Hopkins, Scarlett et al. (2015) Characterising the reproducibility and reliability of dietary patterns among Yup'ik Alaska Native people. Br J Nutr 113:634-43|
|Trinidad, Susan Brown; Ludman, Evette J; Hopkins, Scarlett et al. (2015) Community dissemination and genetic research: moving beyond results reporting. Am J Med Genet A 167:1542-50|
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