Depression is the 3rd leading contributor to the global burden of disease;alcohol and illicit drug use are among the top ten contributors to that burden (World Health Organization The Global Burden of Disease: 2004 Update). In ten years of COBRE funding, the Center for Psychiatric Neuroscience (CPN) at The University of Mississippi Medical Center (UMMC) developed cutting-edge core facilities and expanded its focus to the areas of depression and alcohol dependence. Innovative and muitidisciplinary Center investigators have collaborated in ground breaking observations on the roles of neurons and glia, cerebral vasculature, aging, gender, transcription factors, serotonin and glutamate in depression and alcoholism and many have secured independent funding. Our mission in Phase III is to continue building basic research in the pathophysiology of mental illnesses and psychoactive substance use disorders by promoting mentoring, strengthening research cores and, thereby, to increase NIH funding in Mississippi.
Specific Aims toward reaching this mission are to: 1) provide support to maintain and expand state-of-the-art research cores that are essential to support basic research across the institution and the state, 2) promote a collaborative and muitidisciplinary mentoring environment that supports innovative pilot research, and 3) develop a self-sustaining center of biomedical research excellence supported by investigator-initiated research grants and collaborative program projects. Our synergistic research cores, available across the institution and state-wide to other COBRE and INBRE investigators, will permit the development of mentored projects along a trajectory of using the Imaging Core and the Molecular and Genomics Core to quantify disease-specific pathology in tissues from the Postmortem Brain Core and modeling such pathology in the Animal Behavior Core to develop phenotypic models of psychopathology and explore novel treatments for depression and psychoactive substance use disorders, including alcohol dependence. State-of-the-art research cores will support mentored basic research in search of new strategies of prevention and treatment for these global challenges to mental health.

Public Health Relevance

Depression is a serious, persistent and potentially lethal illness affecting the mood, activity and physical health of nearly 10 million American adults per year, while 7 percent of adult Americans are alcohol dependent. A mentored basic research pilot program examining the pathophysiology of these illnesses, supported by state-of-the-art research cores, will seek new strategies of prevention and treatment.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Program Officer
Douthard, Regine
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Mississippi Medical Center
Schools of Medicine
United States
Zip Code
Rubinow, Marisa J; Mahajan, Gouri; May, Warren et al. (2014) Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study. Brain Struct Funct :
Enwerem, Isioma I; Velma, Venkatramreddy; Broome, Hanna J et al. (2014) Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis. Biol Open 3:240-9
Singh, Ramesh; Pochampally, Radhika; Watabe, Kounosuke et al. (2014) Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer. Mol Cancer 13:256
Szebeni, Attila; Szebeni, Katalin; DiPeri, Timothy et al. (2014) Shortened telomere length in white matter oligodendrocytes in major depression: potential role of oxidative stress. Int J Neuropsychopharmacol 17:1579-89
Chandley, Michelle J; Szebeni, Attila; Szebeni, Katalin et al. (2014) Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression. Int J Neuropsychopharmacol 17:1569-78
Miguel-Hidalgo, José Javier; Wilson, Barbara A; Hussain, Syed et al. (2014) Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression. J Psychiatr Res 55:101-9
George, Eric M; Garrett, Michael R; Granger, Joey P (2014) Placental ischemia induces changes in gene expression in chorionic tissue. Mamm Genome 25:253-61
Westbrook, Lindsey; Johnson, Ashley C; Regner, Kevin R et al. (2014) Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. J Am Soc Nephrol 25:2499-510
Miguel-Hidalgo, Jose J; Whittom, Angela; Villarreal, Ashley et al. (2014) Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder. J Affect Disord 158:62-70
Whittom, Angela; Villarreal, Ashley; Soni, Madhav et al. (2014) Markers of apoptosis induction and proliferation in the orbitofrontal cortex in alcohol dependence. Alcohol Clin Exp Res 38:2790-9

Showing the most recent 10 out of 11 publications