Neurodegenerative disease research is one of UND's few recognized strengths as identified in 3 separate Strategic research reports. This COBRE Phase 111 funding request will support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders. Since our COBRE funding started 9 years ago, we supported 11 project directors, we developed and supported two cores, we supported the hiring of 9 neuroscience faculty, and we supported with pilot grants 16 neuroscience investigators. COBRE investigators received about $11M in extramural grants, published 242 manuscripts, and a new Neuroscience Research Building was built. Our Mass Spectrometry Core Facility is used almost exclusively for small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. The equipment housed in our facility includes a new Waters Synapt G2 QTOF with UPLC and Nanomate, an API-3000 triple quadripole with HPLC, a QSTAR with nanoLC, a Polaris Q ion trap with GC, and a Beckman 2-D HPLC. Our Imaging Core Facility provides access to fluorescence, confocal, multiphoton, and electron microscopy instrumentation. The equipment housed in our facility includes two confocal microscopes (Zeiss 510 META LSCM, Olympus FV300 LSCM), a Zeiss ConfoCor2 fluorescence correlation spectroscopy unit, an Olympus FV1000MPE Basic multiphoton/visible confocal microscope system, and two fluorescence microscopes (Nikon TE300 equipped for FURA2 and CFP/YFP FRET ratiometric imaging, and a Nikon Eclipse 801). For electron microscopy, we have a scanning (Hitachi 4700) and a transmission (Hitachi 7500) electron microscope, Reichert ultra-microtomes, and a range of ancillary equipment. The COBRE grant-supported neurodegenerative disease research group has been supported strongly by UND, our successes are recognized by UND, and UND is fully committed to helping sustain our efforts after COBRE funding ends.

Public Health Relevance

COBRE Phase III funding will (1) support 2 cores essential to our neuroscience COBRE group as well as other biomedical researchers, (2) support our pilot grant program that enables investigators to generate data necessary for getting their respective grants funded, and (3) support our administrative core that provides for centralized ordering, a visiting speaker program, library acquisitions, and an annual neuroscience symposium. UND is fully committed to ensuring the sustainability of this group after the COBRE grant ends.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Gorospe, Rafael
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University of North Dakota
Schools of Medicine
Grand Forks
United States
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Brose, Stephen A; Golovko, Svetlana A; Golovko, Mikhail Y (2016) Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. Lipids 51:487-95
Selvaraj, Senthil; Sun, Yuyang; Sukumaran, Pramod et al. (2016) Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway. Mol Carcinog 55:818-31
Schott, Micah B; Gonowolo, Faith; Maliske, Benjamin et al. (2016) FRET biosensors reveal AKAP-mediated shaping of subcellular PKA activity and a novel mode of Ca(2+)/PKA crosstalk. Cell Signal 28:294-306
Martin, Gregory G; Chung, Sarah; Landrock, Danilo et al. (2016) FABP-1 gene ablation impacts brain endocannabinoid system in male mice. J Neurochem 138:407-22
Carballeira, Néstor M; Montano, Nashbly; Amador, Luis A et al. (2016) Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB. Lipids 51:245-56
Soliman, Mahmoud L; Geiger, Jonathan D; Chen, Xuesong (2016) Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. J Neuroimmune Pharmacol :
Ackermann, Karly L; Florke, Rebecca R; Reyes, Shannon S et al. (2016) TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region. J Biol Chem 291:23604-23617
Zhuang, Yan; Li, Yi; Li, Xuefeng et al. (2016) Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway. PLoS One 11:e0149754
Chen, Xuesong; Wagener, John F; Ghribi, Othman et al. (2016) Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci 8:129
Zhang, Shuang; Wu, Min; Gao, Hongwei (2015) Editorial: NFAT signaling: no FAT as new weapon to fight shock. J Leukoc Biol 97:997-9

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