The Clinical Core of the Center for Oral Health Research (C-COHR) emerged from a strong community-based initiative and consolidation of the former Clinical Core and Biostatistics Core, both initiated with the first phase of COBRE funding. By consolidating and further fostering the expertise developed over the last decade of activities in clinical and biostatistical methods needed specifically for oral health research, CCOHR meets a critical need for the established and growing cadre of MUSC investigators incorporating oral health components into their translational and clinical research. The tailored oral health expertise ensures the unique position of C-COHR among research facilities at MUSC and, more broadly, in South Carolina, supporting projects investigating the relationships between oral health and systemic disorders; evaluating new oral diagnostic and intervention methods;and that are active community interventions aiming to decrease oral health disparities in our state, especially among the underserved Gullah population and at the same time developing models that can be widely applied. The objective of C-COHR is to optimize the clinical research process engaging academic and community partners in the development of clinical research that will enable the MUSC research team to effectively bring their dental and educational expertise into the Gullah and/or other minority communities. The CCOHR has established the infrastructure to engage disparity populations in South Carolina and is on course towards becoming independent with community-based, clinical and biostatistical investigators. Through further synergy with other programs, our unique oral health program will strengthen biomedical, clinical and behavioral oral health research capacity on campus and address the otherwise unmet needs of investigators pursuing oral health clinical and community-based research hypotheses;and of engaging our unique population, the Gullah African Americans. As a result, we expect to reduce oral health disparities through discovery, and development of knowledge and interventions.

Public Health Relevance

C-COHR is an essential resource to conduct oral health research, that provides necessary physical as well as human infrastructure with clinical and laboratory capacities and in addition provides unique expertise in clinical, community-based and biostatistical issues relevant to Oral Health research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B (01))
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Medical University of South Carolina
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Bartee, Mee Y; Dunlap, Katherine M; Bartee, Eric (2016) Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells. Clin Lymphoma Myeloma Leuk 16:203-12
Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J et al. (2016) Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature 530:358-61
Herbert, B A; Novince, C M; Kirkwood, K L (2016) Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. Mol Oral Microbiol 31:207-27
Valerio, M S; Basilakos, D S; Kirkpatrick, J E et al. (2016) Sex-based differential regulation of bacterial-induced bone resorption. J Periodontal Res :
Howie, R Nicole; Durham, Emily L; Black, Laurel et al. (2016) Effects of In Utero Thyroxine Exposure on Murine Cranial Suture Growth. PLoS One 11:e0167805
Rosset, Emilie M; Bradshaw, Amy D (2016) SPARC/osteonectin in mineralized tissue. Matrix Biol 52-54:78-87
Durham, Emily L; Howie, R Nicole; Black, Laurel et al. (2016) Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis. Birth Defects Res A Clin Mol Teratol 106:803-813
Shahrabi-Farahani, Shokoufeh; Gallottini, Marina; Martins, Fabiana et al. (2016) Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma. Am J Pathol 186:1055-64
Link, Laura A; Howley, Breege V; Hussey, George S et al. (2016) PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res 14:634-46
Yu, H; Sun, C; Argraves, K M (2016) Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice. J Periodontal Res 51:38-49

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