The principal objective of the COHR Pilot and Feasibility Project Program is to provide and prioritize short term funding for scientifically meritorious, new and innovative projects through a competitive program with open solicitation, peer review, and funding in three categories: Early Career, New Direction, and Novel Methods &Technology. The ultimate goal of the program is to provide adequate resources and training for pilot investigators to develop sufficient preliminary data to prepare a competitive extramural grant application that will directly utilize one or more of the COHR cores. The program will have a three part focus with a mission to: 1) attract junior faculty without prior extramural funding to oral health-related research;2) enable established COHR investigators to explore an area that represents a significant departure from their currently funded work, and 3) entice established investigators in other areas of biomedical research to apply their expertise to an oral health-related problem. Request for applications (RFA) will be solicited annually four months in advance of the anticipated award date. Funds will be awarded through a two-phase application process which will include a pre-proposal for all applications, and a full application for competitively selected pre-proposal applicants. Applications will be scored using the NIH scale and prioritized according to four criteria: 1) quality of the research (scientific merit, innovation, and impact);2) relevance to the mission of the Center and direct involvement of one or more COHR Cores in the research plan;3) qualifications of the research team to lead the research effort toward securing extramural funding, and 4) stimulation of collaborative efforts with COHR members. We plan to fund four new and/or continuation projects per year on average. Eligible investigators will receive one to two years of support along with the resources necessary to explore investigator-inititated projects related to the mission of the COHR. Thus, it is envisioned that the Pilot and Feasibility Project Program will enable investigators to form interdisciplinary, interactive and sustainable research studies that will impact oral health.

Public Health Relevance

The national health expenditures for dental services exceeded $102 billion in 2009. Oral diseases and craniofacial disorders are linked to total health and wellbeing throughout life. Virtually everyone has had at least one oral disease, e.g., dental caries, periodontal disease, cold sores or cancer. Many suffer from oral and facial pain. General risk factors, such as tobacco use and poor dietary practices, affect oral/craniofacial health. Data show a connection between oral health and chronic illnesses such as diabetes and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103331-02
Application #
8540447
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$288,203
Indirect Cost
$92,811
Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Bartee, Mee Y; Dunlap, Katherine M; Bartee, Eric (2016) Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells. Clin Lymphoma Myeloma Leuk 16:203-12
Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J et al. (2016) Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature 530:358-61
Herbert, B A; Novince, C M; Kirkwood, K L (2016) Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. Mol Oral Microbiol 31:207-27
Valerio, M S; Basilakos, D S; Kirkpatrick, J E et al. (2016) Sex-based differential regulation of bacterial-induced bone resorption. J Periodontal Res :
Howie, R Nicole; Durham, Emily L; Black, Laurel et al. (2016) Effects of In Utero Thyroxine Exposure on Murine Cranial Suture Growth. PLoS One 11:e0167805
Rosset, Emilie M; Bradshaw, Amy D (2016) SPARC/osteonectin in mineralized tissue. Matrix Biol 52-54:78-87
Durham, Emily L; Howie, R Nicole; Black, Laurel et al. (2016) Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis. Birth Defects Res A Clin Mol Teratol 106:803-813
Shahrabi-Farahani, Shokoufeh; Gallottini, Marina; Martins, Fabiana et al. (2016) Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma. Am J Pathol 186:1055-64
Link, Laura A; Howley, Breege V; Hussey, George S et al. (2016) PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res 14:634-46
Yu, H; Sun, C; Argraves, K M (2016) Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice. J Periodontal Res 51:38-49

Showing the most recent 10 out of 47 publications