With Phase III COBRE support, the MUSC Center for Oral Health Research (COHR) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in oral health. The COHR was conceived to expand the critical mass of funded investigators at MUSC in oral and craniofacial research and to enhance scientific core resources that serve as platforms to increase the capacity of our faculty to compete successfully for NIH funding. The COHR has mentored a total of 28 junior investigators to date, of which 17 have been promoted and 3 have earned tenure;23 of the 28 have been retained at our institution. As a group, they have published more than 250 peer-reviewed papers and abstracts. They have received support from a total of 50 extramural grants, including 24 NIH grants on which they serve as PI or Key Personnel. The major components of this proposal are: A) The Administrative Core providing organizational, coordinating, fiscal and accountability functions;B) The Laboratory Core (L-COHR) providing services through four interactive facilities--the Gnotobiotic Animal Research Facility, Mineralized Tissue Facility, Oral Cancer Research Facility, and Laser Capture Microdissection Facility;C) The Clinical Core (C-COHR) fostering clinical and translational research and stimulating research discoveries through community-based participatory research;and D) The Pilot Project and Feasibility Projects Program providing support for pilot studies to foster research projects that utilize Center resources, personnel and facilities and facilitate interaction with COHR members. The COHR also has an NIH-funded research training component (T-COHR) that complements this proposal. The COHR's growth and activities have fueled a major cultural shift in the College of Dental Medicine and fostered recognition for oral health research at both campus and national levels. Research discoveries and grant success have created an interactive, supportive environment for research in the College of Dental Medicine. Thus, the Center for Oral Health Research is strategically positioned for long-term success as a critical resource for investigators developing new technologies, therapeutics and interventions to enhance the oral health of people in South Carolina and the United States.

Public Health Relevance

The national health expenditures for dental services exceeded $102 billion in 2009. Oral diseases and craniofacial disorders are linked to total health and wellbeing throughout life. Virtually everyone has had at least one oral disease, e.g., dental caries, periodontal disease, cold sores or cancer. Many suffer from oral and facial pain. General risk factors, such as tobacco use and poor dietary practices, affect oral/craniofacial health. Data show a connection between oral health and chronic illnesses such as diabetes and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103331-03
Application #
8676547
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Canto, Maria Teresa
Project Start
2012-09-05
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$1,038,235
Indirect Cost
$334,347
Name
Medical University of South Carolina
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Janakiraman, H; House, R P; Talwar, S et al. (2017) Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. Oncogene 36:3137-3148
Passos, Dario Oliveira; Li, Min; Yang, Renbin et al. (2017) Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. Science 355:89-92
Alexander-Bryant, Angela A; Zhang, Haiwen; Attaway, Christopher C et al. (2017) Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo. Oral Oncol 72:123-131
Novince, Chad M; Whittow, Carolyn R; Aartun, Johannes D et al. (2017) Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. Sci Rep 7:5747
Durham, Emily; Howie, R Nicole; Parsons, Trish et al. (2017) Thyroxine Exposure Effects on the Cranial Base. Calcif Tissue Int 101:300-311
Lu, Z; Li, Y; Brinson, C W et al. (2017) CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate. Oral Dis 23:210-218
Tan, Yong Zi; Baldwin, Philip R; Davis, Joseph H et al. (2017) Addressing preferred specimen orientation in single-particle cryo-EM through tilting. Nat Methods 14:793-796
Durham, Emily L; Howie, R Nicole; Black, Laurel et al. (2016) Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis. Birth Defects Res A Clin Mol Teratol 106:803-813
Jiang, Yong; Woosley, Alec N; Sivalingam, Nageswaran et al. (2016) Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-?-induced autophagy. Nat Cell Biol 18:851-63
Vanden Berg-Foels, Wendy S (2016) Mandibular Cartilage Collagen Network Nanostructure: Insights for Regeneration. Cartilage 7:274-83

Showing the most recent 10 out of 55 publications