Full maturation of the Center for Colon Cancer Research (CCCR) requires that successful young faculty whose research programs were initiated and established during Phases I and 11 collaborate with each other and with senior faculty to form interactive teams that have the capacity for creative approaches to new and challenging problems relevant to colorectal cancer. Thus, during the Phase 111 term, the CCCR will manage a Research Pilot Project Program to foster unique collaborations among center faculty, including both senior and junior investigators. This will be done via the following aims:
Aim 1. To sponsor a seed fund program for investigator-initiated projects related to CRC. The center will entertain applications for new projects that address challenging issues relevant to colorectal cancer. Novel grant applications to the NIH and other agencies will be expected to emerge from this effort.
Aim 2. To promote establishment of multi-disciplinary programs concentrating on specific CRC relevant themes. Teams of investigators that have synergized their expertise around focused themes relating to colorectal cancer will develop competitive program project and center grant applications, as well as novel multi-disciplinary ROIs.
Aim 3. To enhance the ability to recruit and retain graduate students representing underserved minorities. Focus will be on African-Americans, since this represents such a large segment of the population of South Carolina and other states in the southeast region of the US. In all of these aims, the Research Cores and the Administrative Core of the CCCR will play major roles in providing high-end technology, fiscal oversight, clerical support, and monitoring of progress.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM103336-01A1
Application #
8543937
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2013-09-10
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$362,500
Indirect Cost
$112,500
Name
University of South Carolina at Columbia
Department
Type
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Farmaki, E; Chatzistamou, I; Kaza, V et al. (2016) A CCL8 gradient drives breast cancer cell dissemination. Oncogene 35:6309-6318
Peña, Edsel A; Wu, Wensong; Piegorsch, Walter et al. (2016) Model Selection and Estimation with Quantal-Response Data in Benchmark Risk Assessment. Risk Anal :
Kindo, Bereket P; Wang, Hao; Peña, Edsel A (2016) Multinomial probit Bayesian additive regression trees. Stat (Int Stat Inst) 5:119-131
Wallace, Kristin; Brandt, Heather M; Bearden, James D et al. (2016) Race and Prevalence of Large Bowel Polyps Among the Low-Income and Uninsured in South Carolina. Dig Dis Sci 61:265-72
Watson, Shana R; Liu, Piaomu; Peña, Edsel A et al. (2016) Comparison of Aortic Collagen Fiber Angle Distribution in Mouse Models of Atherosclerosis Using Second-Harmonic Generation (SHG) Microscopy. Microsc Microanal 22:55-62
Jung, Joo-Yong; Gleave Parson, Madeline; Kraft, Jennifer D et al. (2016) Elevated interleukin-27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT-1 and STAT-3-dependent manner. Immunology 149:35-47
Patel, Yogin; Shah, Nirav; Lee, Ji Shin et al. (2016) A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth. Oncotarget 7:18295-308
Chatzistamou, Ioulia; Kiaris, Hippokratis (2016) Modeling estrogen receptor-positive breast cancers in mice: is it the best we can do? Endocr Relat Cancer 23:C9-C12
Broude, Eugenia V; Győrffy, Balázs; Chumanevich, Alexander A et al. (2015) Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. Curr Cancer Drug Targets 15:739-49
Levina, Elina; Ji, Hao; Chen, Mengqiang et al. (2015) Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. Oncotarget 6:13088-104

Showing the most recent 10 out of 20 publications