This Phase III COBRE application seeks to support and sustain the momentum achieved during developmental Phases I and II of the Center for Colon Cancer Research (CCCR) at the University of South Carolina. In the US and South Carolina, colorectal cancer remains the 2nd leading cause of cancer death and the 4th highest in incidence. In the 91/2 years since COBRE funding was initiated, the CCCR has made significant strides in enhancing the critical mass of independent scientists studying this disease, as judged by establishment of fully functional laboratories, receipt of extramural research grants, and publication in highly regarded, peer-reviewed journals. In addition, a vibrant outreach program has been designed and implemented to educate citizens from diverse economic backgrounds about colorectal cancer and the value of screening, making South Carolina a national leader in advocacy for this disease. The CCCR is now a fully established, self-standing center that contributes to the nation's goal of reducing the morbidity of colorectal cancer. To carry on with this effort, the CCCR will implement the following aims during Phase III: Provision of administrative services and support through the Administrative Core. Support of financial, programmatic, and training aspects of the CCCR research and outreach effort will be provided. Operation of a group of interactive Research Cores. CCCR investigators will have state-of-the-art expertise and technology available through four Cores, each of which is led by an experienced and knowledgeable member of the CCCR faculty. Oversight of a Research Pilot Project Program. Through fiscal support for development of investigator initiated seed projects, as well as development of multi-disciplinary programs, the Pilot Project effort will enable entry into challenging new research areas, and will mediate unique collaborations. In addition, the project will manage a graduate scholarship program for underserved minorities. In all, the wide range of knowledge and proficiency exhibited by the interdisciplinary faculty comprising the CCCR provides the basis for sustaining, during Phase III period, that which was built during Phases I and II.

Public Health Relevance

Colorectal cancer is diagnosed in over 140,000 Americans each year, and takes 51,000 lives. There is need for focused research on this disease in order to identify and implement improved strategies for diagnosing, preventing, and treating it. Such is the goal of the Center for Colon Cancer Research at the University of South Carolina.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZGM1-TWD-C (C3))
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Gorospe, Rafael
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University of South Carolina at Columbia
Schools of Arts and Sciences
United States
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Oliver, David; Ji, Hao; Liu, Piaomu et al. (2017) Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep 7:43023
Farmaki, Elena; Kaza, Vimala; Papavassiliou, Athanasios G et al. (2017) Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3. Cancer Lett 389:49-58
Brown, Jacob L; Rosa-Caldwell, Megan E; Lee, David E et al. (2017) Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice. J Cachexia Sarcopenia Muscle 8:926-938
Alexander, M; Burch, J B; Steck, S E et al. (2017) Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis 32:183-192
McDermott, Martina S J; Chumanevich, Alexander A; Lim, Chang-Uk et al. (2017) Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget 8:12558-12575
Zhang, Yu; Davis, Celestia; Shah, Sapana et al. (2017) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56:272-287
Chandrashekaran, Varun; Seth, Ratanesh K; Dattaroy, Diptadip et al. (2017) HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol 13:8-19
Farmaki, E; Chatzistamou, I; Kaza, V et al. (2016) A CCL8 gradient drives breast cancer cell dissemination. Oncogene 35:6309-6318
Narsale, Aditi A; Puppa, Melissa J; Hardee, Justin P et al. (2016) Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice. Oncotarget 7:59482-59502
Peña, Edsel A (2016) Asymptotics for a Class of Dynamic Recurrent Event Models. J Nonparametr Stat 28:716-735

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