; The Pilot Project Program will provide funding for pilot projects and bridge funding as well as mentoring for junior investigators. We will provide a mechanism for investigators to apply for funding ($50,000-$100,000/annually) once a year. Total available funds will be $200,000/year. Dr. Shohet or Dr. Boisvert will review the applications and assign them to two scientific experts for peer-review following the NIH peer review format. After initial vetting arranged and coordinated by the Pilot Project Executive Committee the External Advisory Board will review the best applications to choose those that will be funded, based on merit and cardiovascular significance. All applicants will receive a summary statement. The objective will be to enhance the applicant's ability to reach research independence and national competitiveness. Three investigators that received modest pilot project funding during the last cycle have received (or are about to receive) substantial national funding for their work. These were the ONLY three projects funded during the last cycle as """"""""pilot projects"""""""" and all three scientists are now well on their way to stable positions in our Medical Center Our goal is that the Pilot Project-Bridging Program will stimulate and advance extramural funding of meritorious cardiovascular proposals.
Our specific aims encompass the two types of investigators we plan to support:
Specific Aim 1 : To allow new biomedical researchers to generate preliminary data for submission of grant applications related to cardiovascular pathology. We will create a rigorous and fair two step review process to select the most exciting science and the candidates most likely to succeed. We will provide mentoring to successful candidates based on the approach that worked well in the second cycle of the Cardiovascular COBRE.
Specific Aim 2 : To provide support to investigators with a formed application who require modest additional work to bring their grant to successful funding. We will support investigators with scored but unfunded R series grants of cardiovascular significance.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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University of Hawaii
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Sun, Zuyue; Schriewer, Jill; Tang, Mingxin et al. (2016) The TGF-β pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol 90:129-38
Lee, Amanda J; Polgar, Noemi; Napoli, Josephine A et al. (2016) Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Sci Rep 6:31137
DeMartini, E E; Howard, K G (2016) Comparisons of body sizes at sexual maturity and at sex change in the parrotfishes of Hawaii: input needed for management regulations and stock assessments. J Fish Biol 88:523-41
Chew, Glen M; Fujita, Tsuyoshi; Webb, Gabriela M et al. (2016) TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog 12:e1005349
Gu, Se Hun; Arai, Satoru; Yu, Hon-Tsen et al. (2016) Genetic variants of Cao Bang hantavirus in the Chinese mole shrew (Anourosorex squamipes) and Taiwanese mole shrew (Anourosorex yamashinai). Infect Genet Evol 40:113-8
Anderson, C D; Moisyadi, S; Avelar, A et al. (2016) Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice. Gene Ther 23:510-9
Pinto, Alexander R; Ilinykh, Alexei; Ivey, Malina J et al. (2016) Revisiting Cardiac Cellular Composition. Circ Res 118:400-9
Gu, Se Hun; Kumar, Mukesh; Sikorska, Beata et al. (2016) Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea). Sci Rep 6:21119
Cabrera-Fuentes, Hector A; Alba-Alba, Corina; Aragones, Julian et al. (2016) Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside. Basic Res Cardiol 111:7
Cabrera-Fuentes, Hector A; Lopez, Mercedes L; McCurdy, Sara et al. (2015) Regulation of monocyte/macrophage polarisation by extracellular RNA. Thromb Haemost 113:473-81

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