Our long term goal is to establish an NCI designated cancer center for West Virginia (WV) and the surrounding Appalachian region. West Virginia University (WVU) is the flagship university and medical center in the state with no cancer centers in WV currently having NCI designation. Our Phase I-II CoBREs for Signal Transduction and Cancer (P20) were designed to support basic research development as a .critical component of successfully competing for a Cancer Center Support Grant (CCSG) and coincident NCI designation for the WVU Mary Babb Randolph Cancer Center (MBRCC).
The specific aims of our Phase I and Phase II CoBREs evolved from an initial focus on junior investigators with a primary goal of nurturing career development and independent funding (Phase I) to a combination of continued support of junior investigators with establishment of a critical mass in targeted thematic areas during Phase II. In addition, the establishment and strengthening of essential core facilities was supported during Phases I-II and the final stage of this critical core and infrastructure support defines the focus of our Phase III (PSO) Transition Award. Established scientific thematic areas in the MBRCC include Programs focused on the Molecular Mechanisms of EMT and Metastasis, Breast Cancer, Hematopoietic Malignancies and Transplantation, and Translational Tobacco Reduction Research. These Programs provide a structured atmosphere for collaboration and mentoring for the MBRCC members and the platform in which to shape multi-investigator and programmatic grant applications. Relevant to this Transition Award application, projects throughout all of these Programs are supported by the Cores for which support is requested: Flow Cytometry, Microscope Imaging, Animal Models and Imaging, Protein, Biostatistics and Bioinformatics, and Biospecimen Processing.
The specific aims of this Phase III Transition Award include (1) support of state-of-the-art technology and expertise in sustainable core facilities that emphasize accessibility and training in which we nurture career development of investigators undertaking cancer related research and (2) enhanced collaboration in the MBRCC, WVU and the state to maximize the impact of CoBRE investment to ensure maximum access to technology required for high quality, extramurally funded research. Emphasis has been placed on strategies to support collaboration, sustainability, and an avoidance of redundant investment to yield the greatest impact of this award on continued growth of the MBRCC, in part, through availability of outstanding core facility support. Collectively, these efforts support our long-term goal of NCI designation.

Public Health Relevance

WV is characterized by unique health disparities which drive the design of our scientific Programs of focus. CoBRE support has allowed training of scientists, core facility development, and programmatic growth to underpin research that directly contributes to impacting positively on the health of WV residents with diverse malignancies. These successes contribute to our capacity to gain NCI designation which will further strengthen our capacity for research, training and top notch clinical care for residents of the state.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
8P30GM103488-02
Application #
8299627
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Liu, Yanping
Project Start
2011-07-15
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$1,110,000
Indirect Cost
$360,000
Name
West Virginia University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Jajosky, Audrey N; Coad, James E; Vos, Jeffrey A et al. (2014) RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med 3:836-48
Croston, Tara L; Thapa, Dharendra; Holden, Anthony A et al. (2014) Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart. Am J Physiol Heart Circ Physiol 307:H54-65
Magro, Albert; Magro, Alice; Shrestha, Sirish et al. (2014) Metalloproteinase dependent reduction of cell surface cluster determinants upon the induction of apoptosis. Int J Oncol 44:1539-50
Luanpitpong, Sudjit; Chen, Michael; Knuckles, Travis et al. (2014) Appalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formation. Environ Sci Technol 48:12912-9
Armstead, Andrea L; Arena, Christopher B; Li, Bingyun (2014) Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro. Toxicol Appl Pharmacol 278:1-8
Luanpitpong, Sudjit; Wang, Liying; Castranova, Vincent et al. (2014) Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes. Part Fibre Toxicol 11:22
McLaughlin, Sarah L; Ice, Ryan J; Rajulapati, Anuradha et al. (2014) NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. Mol Cancer Res 12:69-81
Kozyreva, Varvara K; McLaughlin, Sarah L; Livengood, Ryan H et al. (2014) NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res 12:681-93
Olfert, I Mark; Malek, Moh H; Eagan, Tomas M L et al. (2014) Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy. BMC Pulm Med 14:106
Sinha, Satyabrata; Belcastro, Marycharmain; Datta, Poppy et al. (2014) Essential role of the chaperonin CCT in rod outer segment biogenesis. Invest Ophthalmol Vis Sci 55:3775-85

Showing the most recent 10 out of 21 publications