Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent livestock and human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at Montana State University (MSU), with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities and equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a coiiesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. The primary objectives in COBRE III will be to continue to expand the capabilities and use of the Animal Models Core, and position it for long-term sustainability.
Four specific Aims will be pursued to address these objectives:
Specific Aim 1 : To provide and maintain state-of-the-art facilities for research involving animal models in support of COBRE-funded Pilot Grants, as well as all other Center and MSU research programs, including access to the Animal Resources Center (ARC), small animal BSL-2 and BSL-3 facilities, and a large animal ABSL-2 facility;
Specific Aim 2 : To provide instruction, mentoring, and expertise that encourages, guides, and fosters advanced strategic use of animal models by Center investigators and other biomedical researchers at MSU;
Specific Aim 3 : To expand, improve, and encourage use of advanced small animal models or relevant large animal models for biomedical research to help investigators select more appropriate or more advanced models and by improving strategies for colony maintenance, husbandry, genetic analyses, and production;
and Specific Aim 4 : To use ongoing assessment to guide further improvement and evolution of the Animal Models Core to better meet users' needs and to help ensure sustainability beyond COBRE III. One of the linchpins for an active, vibrant research environment is interdisciplinary collaboration. Therefore, in evolving toward sustainability, the COBRE III Animal Models Core will offer its services to all interested animal users at MSU, thus building the interactions and collaborations that will lead to long-term research vitality.

Public Health Relevance

The Animal Models Core provides the infrastructure and organizational support necessary for effective efficient use of animals in biomedical research. Animal models are of central importance to research on zoonotic and emerging diseases, and the Animal Models Core will facilitate accomplishment of the goals of COBRE Phase III, thus leading to a sustainable Centerof Biomedical Research Excellence.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
1P30GM110732-01
Application #
8751041
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Montana State University - Bozeman
Department
Type
DUNS #
City
Bozeman
State
MT
Country
United States
Zip Code
59717
Giovannoni, Maria Paola; Schepetkin, Igor A; Crocetti, Letizia et al. (2016) Cinnoline derivatives as human neutrophil elastase inhibitors. J Enzyme Inhib Med Chem 31:628-39
Siemsen, Dan W; Dobrinen, Erin; Han, Soo et al. (2016) Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration. Am J Pathol 186:259-69
Vergelli, Claudia; Schepetkin, Igor A; Ciciani, Giovanna et al. (2016) 2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists. Bioorg Med Chem :
Cavigli, Ian; Daughenbaugh, Katie F; Martin, Madison et al. (2016) Pathogen prevalence and abundance in honey bee colonies involved in almond pollination. Apidologie 47:251-266
Schepetkin, Igor A; Ramstead, Andrew G; Kirpotina, Liliya N et al. (2016) Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed). Phytother Res 30:1287-97
McMenamin, Alexander J; Brutscher, Laura M; Glenny, William et al. (2016) Abiotic and biotic factors affecting the replication and pathogenicity of bee viruses. Curr Opin Insect Sci 16:14-21
Di Cesare Mannelli, Lorenzo; Micheli, Laura; Cinci, Lorenzo et al. (2016) Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis. Rheumatology (Oxford) 55:1285-94
Manlove, Kezia; Cassirer, E Frances; Cross, Paul C et al. (2016) Disease introduction is associated with a phase transition in bighorn sheep demographics. Ecology 97:2593-2602
Schepetkin, Igor A; Khlebnikov, Andrei I; Kirpotina, Liliya N et al. (2016) Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives. Int Immunopharmacol 37:43-58
Vergelli, Claudia; Schepetkin, Igor A; Ciciani, Giovanna et al. (2016) Synthesis of Five- and Six-Membered N-Phenylacetamido Substituted Heterocycles as Formyl Peptide Receptor Agonists. Drug Dev Res :

Showing the most recent 10 out of 64 publications