The ability to view, measure and record characteristics of biological samples or an organism's behavior lies at the heart of scientific investigation. The overall objective ofthe Integrative Imaging Core (IIC) is to provide skilled and knowledgeable staff to apply state-of-the-art imaging-based technologies to KIDDRC research programs. HC is the product of systematic evolution devoted to meeting the imaging needs of KIDDRC investigators. Originally established in 1978 as a histology core, it evolved and expanded to incorporate image analysis in 1990, was enhanced with the advent of digital imaging in 1997, and incorporated microarray capabilifies in 2002. The core underwent a transformation in 2007 when it moved to space designed specifically for the HC in the Hemenway Life Sciences Innovation Center (HLSIC) and received over $3M for major equipment. The HC confinues to evolve with the establishment of a formal partnership with the Hoglund Brain Imaging Center (HBIC). HC incorporates into one package a variety of resources with the common thread that they are all based on approaches that incorporate or support imaging technologies (a microarray scanner is, after all, little more than a fancy confocal microscope). We have attempted to integrate these technologies as a continuum;from molecule to cell to whole organism, and many KIDDRC programs embrace all or a part of this confinuum. The vertical integration of HC facilitates access and coordination of these technologies by providing centralization and one-stop shopping, and encourages Pls to adopt multidisciplinary approaches to research problems.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kansas Lawrence
United States
Zip Code
Ledgerwood, Levi G; Kumar, Dhruv; Eterovic, Agda Karina et al. (2016) The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget 7:27185-98
Morris, Jill K; Vidoni, Eric D; Wilkins, Heather M et al. (2016) Impaired fasting glucose is associated with increased regional cerebral amyloid. Neurobiol Aging 44:138-42
Belousov, Andrei B; Fontes, Joseph D (2016) Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death. Neural Regen Res 11:75-6
Parsel, S M; Grandis, J R; Thomas, S M (2016) Nucleic acid targeting: towards personalized therapy for head and neck cancer. Oncogene 35:3217-26
Bruce, Amanda S; Pruitt, Stephen W; Ha, Oh-Ryeong et al. (2016) The Influence of Televised Food Commercials on Children's Food Choices: Evidence from Ventromedial Prefrontal Cortex Activations. J Pediatr 177:27-32.e1
Marcario, Joanne K; Pendyala, Gurudutt; Riazi, Mariam et al. (2016) Effects of Morphine on Behavioral Task Performance in SIV-Infected Rhesus Macaques. J Neuroimmune Pharmacol 11:348-57
Raider, Kayla; Ma, Delin; Harris, Janna L et al. (2016) A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochem Int 97:172-80
Saunders, Kathryn J; Hine, Kathleen; Hayashi, Yusuke et al. (2016) Adventitious Reinforcement of Maladaptive Stimulus Control Interferes with Learning. Behav Anal Pract 9:223-9
Wilson, Nathan R; Olm-Shipman, Adam J; Acevedo, Diana S et al. (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6:17735
Pierce, Angela N; Di Silvestro, Elizabeth R; Eller, Olivia C et al. (2016) Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress. Brain Res 1639:58-73

Showing the most recent 10 out of 447 publications