The North Carolina Mental Retardation Program (MRRC) represents a diverse and coordinated programmatic endeavor to advance knowledge concerning etiological factors and treatment strategies in mental retardation. The MRRC is administered under the co-directorship of Drs. K. Suzuki (a neurobiologist) and S. Landesman (a developmental psychologist). The majority of research activities are located administratively in the Biological Sciences Research Center (BSRC) and the Frank Porter Graham Child Development Center (FPG) at UNC-Chapel Hill. The MRRC operates as a integrated program that seeks to establish an optimal interdisciplinary environment by providing an Adminstrative Core and four other research-related Core Units: (a) the Computer-Electronics Support Unit (R. Mailman, Director) to adapt hardware and software for computers used by investigators and to design and repair equipment; (b) the Design and Statistical Computing Unit (R. Helms, Director) to provide biostatistical consultation and data analytic services, as well as to develop innovative statistical procedures for multivariate, longitudinal inquiry; (c) the Longitudinal Studies Unit (C. Ramey, Director) to track subjects and to archive valuable data concerning subjects cohorts participating in long-term miltidisciplinary studies; and (d) the Nucleic Acid Laboratory (K. Suzuki, Director) to provide common, semi-routine procedures in recombinant DNA technology. The MRRC has a Research Affiliate program to identify scientists engaged in high quality research relevant to mental retardaztion and thereby eligible to use Core Services. Major areas of programmatic investigation are delineated as """"""""Sections"""""""" and Section Heads hold monthly meetings to plan, coordinate, and review program activities. An Interdisciplinary Lecture Series fosters sharing of new findings and concepts. The UNC-Chapel Hill and State of North Crolina provide extensive support to the MRRC. In this application, diverse means are described to encourage collaborative research here and with scientists at other MRRCs. By efficiently coordinating specialized Core support services and by providing a common administrative framework, this MRRC will facilitate a cost-effective approach to conducting research related to the understanding, treatment, and prevention of mental retardation.
| Lyu, Ilwoo; Kim, Sun Hyung; Girault, Jessica B et al. (2018) A cortical shape-adaptive approach to local gyrification index. Med Image Anal 48:244-258 |
| Klusek, Jessica; Ruber, Alexis; Roberts, Jane E (2018) Impaired eye contact in the FMR1 premutation is not associated with social anxiety or the broad autism phenotype. Clin Neuropsychol 32:1337-1352 |
| Harrop, Clare; Jones, Desiree; Zheng, Shuting et al. (2018) Circumscribed Interests and Attention in Autism: The Role of Biological Sex. J Autism Dev Disord 48:3449-3459 |
| Tu, Liyun; Styner, Martin; Vicory, Jared et al. (2018) Skeletal Shape Correspondence Through Entropy. IEEE Trans Med Imaging 37:1-11 |
| Laxman, D J; Greenberg, J S; DaWalt, L S et al. (2018) Medication use by adolescents and adults with fragile X syndrome. J Intellect Disabil Res 62:94-105 |
| Lyu, Ilwoo; Perdomo, Jonathan; Yapuncich, Gabriel S et al. (2018) Group-wise Shape Correspondence of Variable and Complex Objects. Proc SPIE Int Soc Opt Eng 10574: |
| Nowell, Sallie W; Watson, Linda R; Faldowski, Richard A et al. (2018) An Initial Psychometric Evaluation of the Joint Attention Protocol. J Autism Dev Disord 48:1932-1944 |
| Jha, Shaili C; Xia, Kai; Schmitt, James Eric et al. (2018) Genetic influences on neonatal cortical thickness and surface area. Hum Brain Mapp 39:4998-5013 |
| Barstein, Jamie; Martin, Gary E; Lee, Michelle et al. (2018) A Duck Wearing Boots?! Pragmatic Language Strategies for Repairing Communication Breakdowns Across Genetically Based Neurodevelopmental Disabilities. J Speech Lang Hear Res 61:1440-1454 |
| Woodbury-Smith, Marc; Paterson, Andrew D; O'Connor, Irene et al. (2018) A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees. J Neurodev Disord 10:20 |
Showing the most recent 10 out of 376 publications
