The Core will be administered by Dr. Michael Levine. His role will be to oversee all Core services. Dr. Cepeda will provide training and instruction in electrophysiological assessment and in some cases will help perform the physiological experiments. Core services will be accessed first by consultation with Drs. Levine and Cepeda. The purpose of the consultation will be to determine which services are needed and when and how they might best be provided. Drs. Levine and Cepeda will meet with the investigator to determine the services needed and set up a time-line for provicling the service. Thus, these services are available on a firstcome, first-served basis. IDDRC investigators that need aid in performing electrophysiological analyses will have access to these Core services which are not to our knowledge presently available at UCLA except when collaborations are set up between investigators. Training and/or use of the Core set-ups will be performed according to an individualized schedule that depends on the sophistication and previous experience of the Core user. Electrophysiological experiments are labor intensive and time-consuming. It is our experience that only one investigator (or perhaps two at most depending on the services they need) will be able to use the Core at one time. We expect that most projects will require one to two months to complete (depending on availability of cultured cells and animals when slices are made), although training in electrophysiology may take longer depending on the ability of the person being trained. Once an individual is trained, they will be able to use the facility to perform experiments. The experiments and the data collected will be monitored both by Drs. Levine and Cepeda. Our experience is that weekly meetings with the investigator collecting the data are sufficient for quality control and assessment. The Physiological Assessment Core will interact directly with Core D, Cell Biology and Cellular Imaging to coordinate electrophysiological and imaging experiments on the same animals or on fixed tissue after electrophysiology is performed and Core E, Animal Models Core to determine availability of animals for experiments.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Abad, Catalina; Jayaram, Bhavaani; Becquet, Laurine et al. (2016) VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation 13:169
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:431-49
Condro, Michael C; Matynia, Anna; Foster, Nicholas N et al. (2016) High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons. J Comp Neurol 524:3827-3848
Khankan, Rana R; Griffis, Khris G; Haggerty-Skeans, James R et al. (2016) Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration. J Neurosci 36:6269-86
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Erratum to: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:1844
Espinosa-Jeffrey, Araceli; Nguyen, Kevin; Kumar, Shalini et al. (2016) Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism. J Neurosci Res 94:1434-1450
Espinosa-Jeffrey, Araceli; Blanchi, Bruno; Biancotti, Juan Carlos et al. (2016) Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes. Curr Protoc Stem Cell Biol 38:2D.18.1-2D.18.27
Mittelman-Smith, Melinda A; Wong, Angela M; Kathiresan, Anupama S Q et al. (2015) Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons. Endocrinology 156:2162-73
Weisner, Thomas S; Hay, M Cameron (2015) Practice to research: integrating evidence-based practices with culture and context. Transcult Psychiatry 52:222-43
Valenza, Marta; Chen, Jane Y; Di Paolo, Eleonora et al. (2015) Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice. EMBO Mol Med 7:1547-64

Showing the most recent 10 out of 74 publications