This IDDRC is a collaboration of the Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania (Penn). This renewal application requests support for six core units and three new program development (NPD) projects. The cores are: (1) An Administrative Core (Core A) that provides overall management, including (i) all educational programs, (ii) monthly lecture series, (iii) the NPD projects, and (iv) the Mid-Atlantic Research Consortium, a novel venture that merges physical and intellectual resources of the IDDRCs at Penn, Johns Hopkins University, and Children's National Medical Center;(2) A Biostatistics and Bioinformatics Core (Core B) that provides consultation for study design, statistical analysis, and bioinformatics/genomics;(3) A Molecular Genetics Core (Core C) that provides a centralized facility for DNA sequencing, fluorescent fragment analysis, mutation detection with cosmig contigs, screen of YAC libraries, quantitative PCR analysis, and gene mapping, etc.;(4) An Analytical Neurochemistry Core (Core D) that provides expertise and support with regard to biochemical analyses, including (i) the study of second messenger systems in living cells;(ii) measurements of biogenic amines and amino acids in brain tissues;(iii) mass spectrometry assays of stable isotopes for kinetic studies of metabolite turnover in both whole brain and in vitro systems;(iv) a Proteomics Sub-core that identifies proteins and peptides as well as salient post-translational modifications such as phosphorylation;(5) A Cellular Neuroscience Core (Core E) that provides support and advice with regard to (i) cytoarchitectural analysis, (ii) cell culture, and (iii) optical imaging of circuit function in slice preparations using voltage sensitive dyes;(6) A new Neuroimaging Core (Core F) that supports a variety of in vivo neuroimaging methods in humans and animal models, including (i) MRI, (ii) PET, and (iii) MEG. The investigators have modified each core in response to feedback from our users since the 2004 renewal. The IDDRC services more than 100 NIH-funded projects with an aggregate value of >$12 million per year (>$1.5 million from NICHD). The Center includes an excess of 70 Penn faculty at 15 departments at the Schools of Medicine, Veterinary Medicine, Nursing, the Wistar Institute, and the College of Arts and Sciences.
The overall goal of this Center is to support research that seeks to identify the causes and to develop potential treatments for children with intellectual and/or developmental disabilities. This Center also advocates for research in this area at CHOP/Penn and recruits new talented investigators to the field. The overall purpose is to improve the lives of people who are afflicted with a cognitive or developmental disability.
|Ghanbari, Yasser; Bloy, Luke; Christopher Edgar, J et al. (2015) Joint analysis of band-specific functional connectivity and signal complexity in autism. J Autism Dev Disord 45:444-60|
|Howerton, Alexis R; Roland, Alison V; Bale, Tracy L (2014) Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation. J Neurosci 34:7113-23|
|Lin, Hong; Hsu, Fu-Chun; Baumann, Bailey H et al. (2014) Cortical parvalbumin GABAergic deficits with ?7 nicotinic acetylcholine receptor deletion: implications for schizophrenia. Mol Cell Neurosci 61:163-75|
|Sunnen, C Nicole; Simonet, Jacqueline C; Marsh, Eric D et al. (2014) Arx is required for specification of the zona incerta and reticular nucleus of the thalamus. J Neuropathol Exp Neurol 73:253-61|
|Jackson, Joshua G; O'Donnell, John C; Takano, Hajime et al. (2014) Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters. J Neurosci 34:1613-24|
|Lysko, Daniel E; Putt, Mary; Golden, Jeffrey A (2014) SDF1 reduces interneuron leading process branching through dual regulation of actin and microtubules. J Neurosci 34:4941-62|
|Zhang, Zhe; Hailat, Zeyad; Falk, Marni J et al. (2014) Integrative analysis of independent transcriptome data for rare diseases. Methods 69:315-25|
|Schrier Vergano, Samantha; Rao, Meera; McCormack, Shana et al. (2014) In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans. Mol Genet Metab 111:331-41|
|Brennan, Jonathan; Lignos, Constantine; Embick, David et al. (2014) Spectro-temporal correlates of lexical access during auditory lexical decision. Brain Lang 133:39-46|
|Jager, Jennifer; O'Brien, W Timothy; Manlove, Jessica et al. (2014) Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erb?. Mol Endocrinol 28:490-8|
Showing the most recent 10 out of 250 publications