The Imaging Core is designed to support high quality basic and applied magnetic resonance (MR) imaging research relevant to understanding and preventing the causes of intellectual and developmental disabilities. To accomplish this mission, the core will provide service with two objectives. The first is to foster translational research by enriching interdisciplinary collaboration across basic and clinical sciences using imaging as a bridging research tool. The second is to provide cost-effective, scientifically robust, state-of-theart core services and facilities to maximize the quality and impact of the science produced by center investigators and their collaborators. The scientific leadership of the Imaging Core will be actively integrated with that of both the human and animal model clinical cores to optimize the application of imaging as a translational tool for center investigators and their collaborators. The Imaging Core will include resources and personnel related to several MR imaging approaches applicable to both human and animal studies. The modalities available will include: ? Conventional imaging including post-acquisition analysis of volumetry and cartography ? Diffusion tensor imaging ? Functional MRI and functional connectivity MRI This proposal builds on existing strengths at Washington University. These strengths include: 1)outstanding physical resources that will be fully optimized for the evaluation of children with developmental disabilities;2) remarkable intellectual resources with expertise in MR imaging and spectroscopy of both human and animal subjects;3) considerable experience in obtaining MR studies of infants and children without sedation;and 4) a diverse, high-quality base of NIH-funded investigators engaged in clinical and translational studies of developmental disabilities that would benefit from this core.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Matthews, Lillian G; Walsh, Brian H; Knutsen, Clare et al. (2018) Brain growth in the NICU: critical periods of tissue-specific expansion. Pediatr Res 83:976-981
Monson, Brian B; Eaton-Rosen, Zach; Kapur, Kush et al. (2018) Differential Rates of Perinatal Maturation of Human Primary and Nonprimary Auditory Cortex. eNeuro 5:
Garcia, Kara E; Robinson, Emma C; Alexopoulos, Dimitrios et al. (2018) Dynamic patterns of cortical expansion during folding of the preterm human brain. Proc Natl Acad Sci U S A 115:3156-3161
El Ters, Nathalie M; Vesoulis, Zachary A; Liao, Steve M et al. (2018) Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants. Early Hum Dev 119:68-72
Sysoeva, Olga V; Constantino, John N; Anokhin, Andrey P (2018) Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study. Mol Autism 9:41
Marrus, Natasha; Kennon-McGill, Stefanie; Harris, Brooke et al. (2018) Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers. J Vis Exp :
Slomine, Beth S; Silverstein, Faye S; Christensen, James R et al. (2018) Neurobehavioural outcomes in children after In-Hospital cardiac arrest. Resuscitation 124:80-89
Vesoulis, Zachary A; Rhoades, Janine; Muniyandi, Pournika et al. (2018) Delayed cord clamping and inotrope use in preterm infants. J Matern Fetal Neonatal Med 31:1327-1334
Church, Joseph T; Werner, Nicole L; Coughlin, Meghan A et al. (2018) Effects of an artificial placenta on brain development and injury in premature lambs. J Pediatr Surg 53:1234-1239
Sylvester, Chad M; Smyser, Christopher D; Smyser, Tara et al. (2018) Cortical Functional Connectivity Evident After Birth and Behavioral Inhibition at Age 2. Am J Psychiatry 175:180-187

Showing the most recent 10 out of 140 publications