The overall objective of the Animal Models Core (AMC) is to use the expertise of current investigators and existing resources at Washington University to improve the lives of those with intellectual and developmental disabilities by promoting the optimal development and assessment of new and existing animal models. Genetic abnormalities and acquired insults account for most intellectual and developmental disabilities. Animal models are a potent tool for obtaining a better understanding of these conditions and developing novel strategies for treating, preventing, and ultimately curing these conditions. Work at Washington University on mouse models of hypoxia ischemia(5), tuberous sclerosis(6) and lysosomal storage diseases(7-9) demonstrates the power of this approach. However, models are available for only a few of the many conditions associated with developmental disability, such as cerebral palsy and autism. Moreover, although causes are known in many instances, the cause of intellectual and developmental disabilities remains unknown for 20-90% of affected individuals.(10) Genomic, proteomic, and metabolomic approaches will help narrow this gap. Simultaneously, standard biochemical approaches will continue to identify novel causes such as cerebral folate deficiency, which was first described in 2002.(11) Nevertheless, the need for animal models will continue to grow. Until now, individual investigators at Washington University developed animal models in their own laboratories. On their own, they found other investigators with the expertise needed to help them develop and assess their models. Informal discussions with these investigators highlighted fruitful collaborations between specific individuals, but also brought to light the fact that many investigators had not taken full advantage of the vast expertise available at the university. Thus, a key goal of the AMC is to bring together several research methodologies into a cohesive functional unit to facilitate the development and assessment of animal models with relevance to intellectual and developmental disabilities. Through these discussions, we identified three specific areas to benefit the research community and have thus divided the AMC into three subcores: ? Genetics/Early Development Subcore: This Subcore will assist investigators with the generation of new animal models using genetic and reproductive/early development techniques. It will assist the development of strategies based on prenatal therapies, gene and stem cell therapy. In addition, it will promote a better understanding of the role of genetic modification in disease processes in IDD. ? Behavior Subcore: This Subcore will provide behavioral assessment of new and current animal models of intellectual and developmental disability. ? Neuropathology Subcore: This Subcore will provide neuropathologlcal assessment of new and current animal models of intellectual and developmental disability.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD062171-04
Application #
8501601
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$232,398
Indirect Cost
$68,207
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Matthews, Lillian G; Walsh, Brian H; Knutsen, Clare et al. (2018) Brain growth in the NICU: critical periods of tissue-specific expansion. Pediatr Res 83:976-981
Monson, Brian B; Eaton-Rosen, Zach; Kapur, Kush et al. (2018) Differential Rates of Perinatal Maturation of Human Primary and Nonprimary Auditory Cortex. eNeuro 5:
Garcia, Kara E; Robinson, Emma C; Alexopoulos, Dimitrios et al. (2018) Dynamic patterns of cortical expansion during folding of the preterm human brain. Proc Natl Acad Sci U S A 115:3156-3161
El Ters, Nathalie M; Vesoulis, Zachary A; Liao, Steve M et al. (2018) Term-equivalent functional brain maturational measures predict neurodevelopmental outcomes in premature infants. Early Hum Dev 119:68-72
Sysoeva, Olga V; Constantino, John N; Anokhin, Andrey P (2018) Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: a family study. Mol Autism 9:41
Marrus, Natasha; Kennon-McGill, Stefanie; Harris, Brooke et al. (2018) Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers. J Vis Exp :
Slomine, Beth S; Silverstein, Faye S; Christensen, James R et al. (2018) Neurobehavioural outcomes in children after In-Hospital cardiac arrest. Resuscitation 124:80-89
Vesoulis, Zachary A; Rhoades, Janine; Muniyandi, Pournika et al. (2018) Delayed cord clamping and inotrope use in preterm infants. J Matern Fetal Neonatal Med 31:1327-1334
Church, Joseph T; Werner, Nicole L; Coughlin, Meghan A et al. (2018) Effects of an artificial placenta on brain development and injury in premature lambs. J Pediatr Surg 53:1234-1239
Sylvester, Chad M; Smyser, Christopher D; Smyser, Tara et al. (2018) Cortical Functional Connectivity Evident After Birth and Behavioral Inhibition at Age 2. Am J Psychiatry 175:180-187

Showing the most recent 10 out of 140 publications